Myeloid PTP1B deficiency protects against atherosclerosis by improving cholesterol homeostasis through an AMPK-dependent mechanism

OBJECTIVE: Atherosclerosis is a chronic inflammatory process induced by the influx and entrapment of excess lipoproteins into the intima media of arteries. Previously, our lab demonstrated that systemic PTP1B inhibition protects against atherosclerosis in preclinical LDLR(−/−) models. Similarly, it...

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Detalles Bibliográficos
Autores principales: Oliver, Helk, Ruta, Dekeryte, Thompson, Dawn, Kamli-Salino, Sarah, Philip, Sam, Wilson, Heather M., Mody, Nimesh, Delibegovic, Mirela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568790/
https://www.ncbi.nlm.nih.gov/pubmed/37828508
http://dx.doi.org/10.1186/s12967-023-04598-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568790/
https://www.ncbi.nlm.nih.gov/pubmed/37828508
http://dx.doi.org/10.1186/s12967-023-04598-2

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