Global analysis of suppressor mutations that rescue human genetic defects

BACKGROUND: Genetic suppression occurs when the deleterious effects of a primary “query” mutation, such as a disease-causing mutation, are rescued by a suppressor mutation elsewhere in the genome. METHODS: To capture existing knowledge on suppression relationships between human genes, we examined 2,...

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Detalles Bibliográficos
Autores principales: Ünlü, Betül, Pons, Carles, Ho, Uyen Linh, Batté, Amandine, Aloy, Patrick, van Leeuwen, Jolanda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568808/
https://www.ncbi.nlm.nih.gov/pubmed/37821946
http://dx.doi.org/10.1186/s13073-023-01232-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568808/
https://www.ncbi.nlm.nih.gov/pubmed/37821946
http://dx.doi.org/10.1186/s13073-023-01232-0

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