Synergistic roles of CBX4 chromo and SIM domains in regulating senescence of primary human osteoarthritic chondrocytes

BACKGROUND: Cellular senescence is a critical factor contributing to osteoarthritis (OA). Overexpression of chromobox homolog 4 (CBX4) in a mouse system was demonstrated to alleviate post-traumatic osteoarthritis (PTOA) by reducing cellular senescence. Additionally, replicative cellular senescence o...

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Detalles Bibliográficos
Autores principales: Chen, Yu-Hsiu, Zhang, Xin, Attarian, David, Kraus, Virginia Byers
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568837/
https://www.ncbi.nlm.nih.gov/pubmed/37828576
http://dx.doi.org/10.1186/s13075-023-03183-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568837/
https://www.ncbi.nlm.nih.gov/pubmed/37828576
http://dx.doi.org/10.1186/s13075-023-03183-8

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