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Synergistic roles of CBX4 chromo and SIM domains in regulating senescence of primary human osteoarthritic chondrocytes

BACKGROUND: Cellular senescence is a critical factor contributing to osteoarthritis (OA). Overexpression of chromobox homolog 4 (CBX4) in a mouse system was demonstrated to alleviate post-traumatic osteoarthritis (PTOA) by reducing cellular senescence. Additionally, replicative cellular senescence o...

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Detalles Bibliográficos
Autores principales:	Chen, Yu-Hsiu, Zhang, Xin, Attarian, David, Kraus, Virginia Byers
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568837/ https://www.ncbi.nlm.nih.gov/pubmed/37828576 http://dx.doi.org/10.1186/s13075-023-03183-8

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