Cholinergic signaling influences the expression of immune checkpoint inhibitors, PD-L1 and PD-L2, and tumor hallmarks in human colorectal cancer tissues and cell lines

BACKGROUND: Cancer cells express immunosuppressive molecules, such as programmed death ligands (PD-L)1 and PD-L2, enabling evasion from the host’s immune system. Cancer cells synthesize and secrete acetylcholine (ACh), acting as an autocrine or paracrine hormone to promote their proliferation, diffe...

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Detalles Bibliográficos
Autores principales: Kuol, Nyanbol, Godlewski, Janusz, Kmiec, Zbigniew, Vogrin, Sara, Fraser, Sarah, Apostolopoulos, Vasso, Nurgali, Kulmira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568879/
https://www.ncbi.nlm.nih.gov/pubmed/37828429
http://dx.doi.org/10.1186/s12885-023-11410-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568879/
https://www.ncbi.nlm.nih.gov/pubmed/37828429
http://dx.doi.org/10.1186/s12885-023-11410-3

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