TACH101, a first-in-class pan-inhibitor of KDM4 histone demethylase

Histone lysine demethylase 4 (KDM4) is an epigenetic regulator that facilitates the transition between transcriptionally silent and active chromatin states by catalyzing the removal of methyl groups on histones H3K9, H3K36, and H1.4K26. KDM4 overamplification or dysregulation has been reported in va...

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Detalles Bibliográficos
Autores principales: Chandhasin, Chandtip, Dang, Van, Perabo, Frank, Del Rosario, Joselyn, Chen, Young K., Filvaroff, Ellen, Stafford, Jeffrey A., Clarke, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Pre-Clinical Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10569680/
https://www.ncbi.nlm.nih.gov/pubmed/37067993
http://dx.doi.org/10.1097/CAD.0000000000001514

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10569680/
https://www.ncbi.nlm.nih.gov/pubmed/37067993
http://dx.doi.org/10.1097/CAD.0000000000001514

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