IS1-related large-scale deletion of chromosomal regions harbouring the oxygen-insensitive nitroreductase gene nfsB causes nitrofurantoin heteroresistance in Escherichia coli

Nitrofurantoin is a broad-spectrum first-line antimicrobial used for managing uncomplicated urinary tract infection (UTI). Loss-of-function mutations in chromosomal genes nfsA, nfsB and ribE of Escherichia coli are known to reduce nitrofurantoin susceptibility. Here, we report the discovery of nitro...

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Detalles Bibliográficos
Autores principales: Wan, Yu, Sabnis, Akshay, Mumin, Zaynab, Potterill, Isabelle, Jauneikaite, Elita, Brown, Colin S., Ellington, Matthew J., Edwards, Andrew, Sriskandan, Shiranee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Microbiology Society 2023
Materias:
Short Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10569738/
https://www.ncbi.nlm.nih.gov/pubmed/37672334
http://dx.doi.org/10.1099/mgen.0.001102

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10569738/
https://www.ncbi.nlm.nih.gov/pubmed/37672334
http://dx.doi.org/10.1099/mgen.0.001102

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