SARS-CoV-2 Nsp8 N-terminal domain folds autonomously and binds dsRNA

The SARS-CoV-2 Nsp8 protein is a critical component of the RNA replicase, as its N-terminal domain (NTD) anchors Nsp12, the RNA, and Nsp13. Whereas its C-terminal domain (CTD) structure is well resolved, there is an open debate regarding the conformation adopted by the NTD as it is predicted as diso...

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Detalles Bibliográficos
Autores principales: Treviño, Miguel Á, Pantoja-Uceda, David, Laurents, Douglas V, Mompeán, Miguel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570013/
https://www.ncbi.nlm.nih.gov/pubmed/37665006
http://dx.doi.org/10.1093/nar/gkad714

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570013/
https://www.ncbi.nlm.nih.gov/pubmed/37665006
http://dx.doi.org/10.1093/nar/gkad714

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