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Structural basis of transcriptional activation by the OmpR/PhoB-family response regulator PmrA

PmrA, an OmpR/PhoB-family response regulator, triggers gene transcription responsible for polymyxin resistance in bacteria by recognizing promoters where the canonical-35 element is replaced by the pmra-box, representing the PmrA recognition sequence. Here, we report a cryo-electron microscopy (cryo...

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Detalles Bibliográficos
Autores principales: Lou, Yuan-Chao, Huang, Hsuan-Yu, Yeh, Hsin-Hong, Chiang, Wei-Hung, Chen, Chinpan, Wu, Kuen-Phon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570014/
https://www.ncbi.nlm.nih.gov/pubmed/37665001
http://dx.doi.org/10.1093/nar/gkad724