Strategies to identify and edit improvements in synthetic genome segments episomally

Genome engineering projects often utilize bacterial artificial chromosomes (BACs) to carry multi-kilobase DNA segments at low copy number. However, all stages of whole-genome engineering have the potential to impose mutations on the synthetic genome that can reduce or eliminate the fitness of the fi...

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Detalles Bibliográficos
Autores principales: Rudolph, Alexandra, Nyerges, Akos, Chiappino-Pepe, Anush, Landon, Matthieu, Baas-Thomas, Maximilien, Church, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Synthetic Biology and Bioengineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570025/
https://www.ncbi.nlm.nih.gov/pubmed/37615546
http://dx.doi.org/10.1093/nar/gkad692

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570025/
https://www.ncbi.nlm.nih.gov/pubmed/37615546
http://dx.doi.org/10.1093/nar/gkad692

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