Cargando…

RAP80 phase separation at DNA double-strand break promotes BRCA1 recruitment

RAP80 has been characterized as a component of the BRCA1-A complex and is responsible for the recruitment of BRCA1 to DNA double-strand breaks (DSBs). However, we and others found that the recruitment of RAP80 and BRCA1 were not absolutely temporally synchronized, indicating that other mechanisms, a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Qin, Caolitao, Wang, Yun-Long, Zhou, Jin-Ying, Shi, Jie, Zhao, Wan-Wen, Zhu, Ya-Xi, Bai, Shao-Mei, Feng, Li-Li, Bie, Shu-Ying, Zeng, Bing, Zheng, Jian, Zeng, Guang-Dong, Feng, Wei-Xing, Wan, Xiang-Bo, Fan, Xin-Juan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570032/ https://www.ncbi.nlm.nih.gov/pubmed/37638744 http://dx.doi.org/10.1093/nar/gkad686

Ejemplares similares

Co-operation of BRCA1 and POH1 relieves the barriers posed by 53BP1 and RAP80 to resection
por: Kakarougkas, Andreas, et al.
Publicado: (2013)

NF-κB regulates DNA double-strand break repair in conjunction with BRCA1–CtIP complexes
por: Volcic, Meta, et al.
Publicado: (2012)

Two separable functions of Ctp1 in the early steps of meiotic DNA double-strand break repair
por: Ma, Lijuan, et al.
Publicado: (2015)

ZMYM2 restricts 53BP1 at DNA double-strand breaks to favor BRCA1 loading and homologous recombination
por: Lee, Doohyung, et al.
Publicado: (2022)

Rad10 exhibits lesion-dependent genetic requirements for recruitment to DNA double-strand breaks in Saccharomyces cerevisiae
por: Moore, Destaye M., et al.
Publicado: (2009)

Distinct spatiotemporal patterns and PARP dependence of XRCC1 recruitment to single-strand break and base excision repair
por: Campalans, Anna, et al.
Publicado: (2013)

SFPQ•NONO and XLF function separately and together to promote DNA double-strand break repair via canonical nonhomologous end joining
por: Jaafar, Lahcen, et al.
Publicado: (2017)

hSSB1 rapidly binds at the sites of DNA double-strand breaks and is required for the efficient recruitment of the MRN complex
por: Richard, Derek J., et al.
Publicado: (2011)

Bcl2 inhibits recruitment of Mre11 complex to DNA double-strand breaks in response to high-linear energy transfer radiation
por: Xie, Maohua, et al.
Publicado: (2015)

DNA ligase III acts as a DNA strand break sensor in the cellular orchestration of DNA strand break repair
por: Abdou, Ismail, et al.
Publicado: (2015)

Pathological mutations in PNKP trigger defects in DNA single-strand break repair but not DNA double-strand break repair
por: Kalasova, Ilona, et al.
Publicado: (2020)

The de-ubiquitylating enzymes USP26 and USP37 regulate homologous recombination by counteracting RAP80
por: Typas, Dimitris, et al.
Publicado: (2015)

Ctp1-dependent clipping and resection of DNA double-strand breaks by Mre11 endonuclease complex are not genetically separable
por: Jensen, Kristi L., et al.
Publicado: (2016)

Transcription-associated recombination is independent of XRCC2 and mechanistically separate from homology-directed DNA double-strand break repair
por: Savolainen, Linda, et al.
Publicado: (2009)

DNA double-strand breaks in heterochromatin elicit fast repair protein recruitment, histone H2AX phosphorylation and relocation to euchromatin
por: Jakob, Burkhard, et al.
Publicado: (2011)

Chromosome thripsis by DNA double strand break clusters causes enhanced cell lethality, chromosomal translocations and 53BP1-recruitment
por: Schipler, Agnes, et al.
Publicado: (2016)

Single-stranded DNA oligomers stimulate error-prone alternative repair of DNA double-strand breaks through hijacking Ku protein
por: Yuan, Ying, et al.
Publicado: (2015)

Double-strand break toxicity is chromatin context independent
por: Friskes, Anoek, et al.
Publicado: (2022)

Dna2 initiates resection at clean DNA double-strand breaks
por: Paudyal, Sharad C., et al.
Publicado: (2017)

APE1 senses DNA single-strand breaks for repair and signaling
por: Lin, Yunfeng, et al.
Publicado: (2020)

hSSB1 interacts directly with the MRN complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activity
por: Richard, Derek J., et al.
Publicado: (2011)

C-terminal region of bacterial Ku controls DNA bridging, DNA threading and recruitment of DNA ligase D for double strand breaks repair
por: McGovern, Stephen, et al.
Publicado: (2016)

Mechanistic analysis of Xenopus EXO1's function in 5′-strand resection at DNA double-strand breaks
por: Liao, Shuren, et al.
Publicado: (2011)

Double-strand break repair deficiency in NONO knockout murine embryonic fibroblasts and compensation by spontaneous upregulation of the PSPC1 paralog
por: Li, Shuyi, et al.
Publicado: (2014)

Marker-free quantification of repair pathway utilization at Cas9-induced double-strand breaks
por: Feng, Wanjuan, et al.
Publicado: (2021)

Human RECQ5 helicase promotes repair of DNA double-strand breaks by synthesis-dependent strand annealing
por: Paliwal, Shreya, et al.
Publicado: (2014)

Flanking strand separation activity of RecA nucleoprotein filaments in DNA strand exchange reactions
por: Yu, Fangzhi, et al.
Publicado: (2023)

ARF induction in response to DNA strand breaks is regulated by PARP1
por: Orlando, Giulia, et al.
Publicado: (2014)

A double-strand break can trigger immunoglobulin gene conversion
por: Bastianello, Giulia, et al.
Publicado: (2017)

Hedgehog signaling enables repair of ribosomal DNA double-strand breaks
por: Lama-Sherpa, Tshering D, et al.
Publicado: (2020)

Architectural plasticity of human BRCA2–RAD51 complexes in DNA break repair
por: Sánchez, Humberto, et al.
Publicado: (2017)

The PARP3- and ATM-dependent phosphorylation of APLF facilitates DNA double-strand break repair
por: Fenton, Amanda L., et al.
Publicado: (2013)

Evidence that MEK1 positively promotes interhomologue double-strand break repair
por: Terentyev, Yaroslav, et al.
Publicado: (2010)

A moonlighting metabolic protein influences repair at DNA double-stranded breaks
por: Torres-Machorro, Ana Lilia, et al.
Publicado: (2015)

Smarcal1 promotes double-strand-break repair by nonhomologous end-joining
por: Keka, Islam Shamima, et al.
Publicado: (2015)

The COP9 signalosome is vital for timely repair of DNA double-strand breaks
por: Meir, Michal, et al.
Publicado: (2015)

Evidence for double-strand break mediated mitochondrial DNA replication in Saccharomyces cerevisiae
por: Prasai, Kanchanjunga, et al.
Publicado: (2017)

Topoisomerase II contributes to DNA secondary structure-mediated double-stranded breaks
por: Szlachta, Karol, et al.
Publicado: (2020)

Single-strand nicks induce homologous recombination with less toxicity than double-strand breaks using an AAV vector template
por: Metzger, Michael J., et al.
Publicado: (2011)

The CSB chromatin remodeler regulates PARP1- and PARP2-mediated single-strand break repair at actively transcribed DNA regions
por: Bilkis, Rabeya, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_mdsm6ohh6ij5097iq50j38bqlq