Cell-type specific regulator RBPMS switches alternative splicing via higher-order oligomerization and heterotypic interactions with other splicing regulators

Alternative pre-mRNA splicing decisions are regulated by RNA binding proteins (RBPs) that can activate or repress regulated splice sites. Repressive RBPs typically harness multivalent interactions to bind stably to target RNAs. Multivalency can be achieved by homomeric oligomerization and heteromeri...

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Detalles Bibliográficos
Autores principales: Yang, Yi, Lee, Giselle C, Nakagaki-Silva, Erick, Huang, Yuling, Peacey, Matthew, Partridge, Ruth, Gooding, Clare, Smith, Christopher W J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570038/
https://www.ncbi.nlm.nih.gov/pubmed/37548402
http://dx.doi.org/10.1093/nar/gkad652

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570038/
https://www.ncbi.nlm.nih.gov/pubmed/37548402
http://dx.doi.org/10.1093/nar/gkad652

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