Precise genome editing of the Kozak sequence enables bidirectional and quantitative modulation of protein translation to anticipated levels without affecting transcription

None of the existing approaches for regulating gene expression can bidirectionally and quantitatively fine-tune gene expression to desired levels. Here, on the basis of precise manipulations of the Kozak sequence, which has a remarkable influence on translation initiation, we proposed and validated...

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Detalles Bibliográficos
Autores principales: Xie, Jingke, Zhuang, Zhenpeng, Gou, Shixue, Zhang, Quanjun, Wang, Xia, Lan, Ting, Lian, Meng, Li, Nan, Liang, Yanhui, Ouyang, Zhen, Ye, Yinghua, Wu, Han, Lai, Liangxue, Wang, Kepin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Synthetic Biology and Bioengineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570039/
https://www.ncbi.nlm.nih.gov/pubmed/37650635
http://dx.doi.org/10.1093/nar/gkad687

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570039/
https://www.ncbi.nlm.nih.gov/pubmed/37650635
http://dx.doi.org/10.1093/nar/gkad687

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