Guide-specific loss of efficiency and off-target reduction with Cas9 variants

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High-fidelity clustered regularly interspaced palindromic repeats (CRISPR)-associated protein 9 (Cas9) variants have been developed to reduce the off-target effects of CRISPR systems at a cost of efficiency loss. To systematically evaluate the efficiency and off-target tolerance of Cas9 variants in...

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Detalles Bibliográficos
Autores principales: Zhang, Liang, He, Wei, Fu, Rongjie, Wang, Shuyue, Chen, Yiwen, Xu, Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570041/
https://www.ncbi.nlm.nih.gov/pubmed/37615574
http://dx.doi.org/10.1093/nar/gkad702

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570041/
https://www.ncbi.nlm.nih.gov/pubmed/37615574
http://dx.doi.org/10.1093/nar/gkad702

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