Novobiocin blocks nucleic acid binding to Polθ and inhibits stimulation of its ATPase activity

Polymerase theta (Polθ) acts in DNA replication and repair, and its inhibition is synthetic lethal in BRCA1 and BRCA2-deficient tumor cells. Novobiocin (NVB) is a first-in-class inhibitor of the Polθ ATPase activity, and it is currently being tested in clinical trials as an anti-cancer drug. Here, w...

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Detalles Bibliográficos
Autores principales: Syed, Aleem, Filandr, Frantisek, Patterson-Fortin, Jeffrey, Bacolla, Albino, Ravindranathan, Ramya, Zhou, Jia, McDonald, Drew T, Albuhluli, Mohammed E, Verway-Cohen, Amy, Newman, Joseph A, Tsai, Miaw-Sheue, Jones, Darin E, Schriemer, David C, D’Andrea, Alan D, Tainer, John A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570058/
https://www.ncbi.nlm.nih.gov/pubmed/37665033
http://dx.doi.org/10.1093/nar/gkad727

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570058/
https://www.ncbi.nlm.nih.gov/pubmed/37665033
http://dx.doi.org/10.1093/nar/gkad727

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