Caveolin‐3 loss linked with the P104L LGMD‐1C mutation modulates skeletal muscle mTORC1 signalling and cholesterol homeostasis

BACKGROUND: Caveolins are the principal structural components of plasma membrane caveolae. Dominant pathogenic mutations in the muscle‐specific caveolin‐3 (Cav3) gene isoform, such as the limb girdle muscular dystrophy type 1C (LGMD‐1C) P104L mutation, result in dramatic loss of the Cav3 protein and...

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Detalles Bibliográficos
Autores principales: Shah, Dinesh S., Nisr, Raid B., Krasteva‐Christ, Gabriela, Hundal, Harinder S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570080/
https://www.ncbi.nlm.nih.gov/pubmed/37671684
http://dx.doi.org/10.1002/jcsm.13317

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570080/
https://www.ncbi.nlm.nih.gov/pubmed/37671684
http://dx.doi.org/10.1002/jcsm.13317

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