Cargando…
The VCAM1–ApoE pathway directs microglial chemotaxis and alleviates Alzheimer’s disease pathology
In Alzheimer’s disease (AD), sensome receptor dysfunction impairs microglial danger-associated molecular pattern (DAMP) clearance and exacerbates disease pathology. Although extrinsic signals, including interleukin-33 (IL-33), can restore microglial DAMP clearance, it remains largely unclear how the...
Autores principales: | Lau, Shun-Fat, Wu, Wei, Wong, Hiu Yi, Ouyang, Li, Qiao, Yi, Xu, Jiahui, Lau, Jessica Hiu-Yan, Wong, Carlton, Jiang, Yuanbing, Holtzman, David M., Fu, Amy K. Y., Ip, Nancy Y. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group US
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570140/ https://www.ncbi.nlm.nih.gov/pubmed/37735240 http://dx.doi.org/10.1038/s43587-023-00491-1 |
Ejemplares similares
-
Cytokine signaling convergence regulates the microglial state transition in Alzheimer’s disease
por: Lau, Shun-Fat, et al.
Publicado: (2021) -
An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer’s disease
por: Jiang, Yuanbing, et al.
Publicado: (2022) -
Melanocortin receptor activation alleviates amyloid pathology and glial reactivity in an Alzheimer’s disease transgenic mouse model
por: Lau, Jackie K. Y., et al.
Publicado: (2021) -
Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer’s disease
por: Lau, Shun-Fat, et al.
Publicado: (2020) -
Quantitative in vivo assessment of amyloid-beta phagocytic capacity in an Alzheimer’s disease mouse model
por: Lau, Shun-Fat, et al.
Publicado: (2021)