Single-Cell RNA Analysis Reveals Cell-Intrinsic Functions of CAR T Cells Correlating with Response in a Phase II Study of Lymphoma Patients

PURPOSE: Although CD19 chimeric antigen receptor T cells (CAR-T) therapy has shown remarkable success in B-cell malignancies, a substantial fraction of patients do not obtain a long-term clinical response. This could be influenced by the quality of the individual CAR-T infusion product. To shed some...

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Detalles Bibliográficos
Autores principales: Sarén, Tina, Ramachandran, Mohanraj, Gammelgård, Gustav, Lövgren, Tanja, Mirabello, Claudio, Björklund, Åsa K., Wikström, Kristina, Hashemi, Jamileh, Freyhult, Eva, Ahlström, Håkan, Amini, Rose-Marie, Hagberg, Hans, Loskog, Angelica, Enblad, Gunilla, Essand, Magnus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Clinical Trials: Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570681/
https://www.ncbi.nlm.nih.gov/pubmed/37540566
http://dx.doi.org/10.1158/1078-0432.CCR-23-0178

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570681/
https://www.ncbi.nlm.nih.gov/pubmed/37540566
http://dx.doi.org/10.1158/1078-0432.CCR-23-0178

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