Toll-Like Receptor 4 Agonist Injection With Concurrent Radiotherapy in Patients With Metastatic Soft Tissue Sarcoma: A Phase 1 Nonrandomized Controlled Trial

IMPORTANCE: Metastatic soft tissue sarcomas (STSs) have limited systemic therapy options, and immunomodulation has not yet meaningfully improved outcomes. Intratumoral (IT) injection of the toll-like receptor 4 (TLR4) agonist glycopyranosyl lipid A in stable-emulsion formulation (GLA-SE) has been st...

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Detalles Bibliográficos
Autores principales: Seo, Yongwoo David, Lu, Hailing, Black, Graeme, Smythe, Kimberly, Yu, Yuexin, Hsu, Cynthia, Ng, Juliana, Hermida de Viveiros, Pedro, Warren, E. Houston, Schroeder, Brett A., O’Malley, Ryan B., Cranmer, Lee D., Loggers, Elizabeth T., Wagner, Michael J., Bonham, Lynn, Pillarisetty, Venu G., Kane, Gabrielle, Berglund, Peter, Hsu, Frank J., Mi, Xinlei, Alexiev, Borislav A., Pierce, Robert H., Riddell, Stanley R., Jones, Robin L., ter Meulen, Jan, Kim, Edward Y., Pollack, Seth M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Medical Association 2023
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570919/
https://www.ncbi.nlm.nih.gov/pubmed/37824131
http://dx.doi.org/10.1001/jamaoncol.2023.4015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570919/
https://www.ncbi.nlm.nih.gov/pubmed/37824131
http://dx.doi.org/10.1001/jamaoncol.2023.4015

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