Forced Fox-P3 expression can improve the safety and antigen-specific function of engineered regulatory T cells

Regulatory T cells (Treg) are potent inhibitors of autoreactive T cells. The intracellular transcription factor FoxP3 controls the expression levels of a diverse set of genes and plays a critical role in programming functional Tregs. Although, antigen-specific Tregs are more potent than polyclonal T...

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Detalles Bibliográficos
Autores principales: McGovern, Jenny, Holler, Angelika, Thomas, Sharyn, Stauss, Hans J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570926/
https://www.ncbi.nlm.nih.gov/pubmed/36049437
http://dx.doi.org/10.1016/j.jaut.2022.102888

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570926/
https://www.ncbi.nlm.nih.gov/pubmed/36049437
http://dx.doi.org/10.1016/j.jaut.2022.102888

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