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Forced Fox-P3 expression can improve the safety and antigen-specific function of engineered regulatory T cells
Regulatory T cells (Treg) are potent inhibitors of autoreactive T cells. The intracellular transcription factor FoxP3 controls the expression levels of a diverse set of genes and plays a critical role in programming functional Tregs. Although, antigen-specific Tregs are more potent than polyclonal T...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Academic Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570926/ https://www.ncbi.nlm.nih.gov/pubmed/36049437 http://dx.doi.org/10.1016/j.jaut.2022.102888 |