Statins markedly potentiate aminopeptidase inhibitor activity against (drug-resistant) human acute myeloid leukemia cells

Aim: This study aimed to decipher the molecular mechanism underlying the synergistic effect of inhibitors of the mevalonate-cholesterol pathway (i.e., statins) and aminopeptidase inhibitors (APis) on APi-sensitive and -resistant acute myeloid leukemia (AML) cells. Methods: U937 cells and their subli...

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Detalles Bibliográficos
Autores principales: Jansen, Gerrit, Al, Marjon, Assaraf, Yehuda G., Kammerer, Sarah, van Meerloo, Johan, Ossenkoppele, Gert J., Cloos, Jacqueline, Peters, Godefridus J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: OAE Publishing Inc. 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10571057/
https://www.ncbi.nlm.nih.gov/pubmed/37842233
http://dx.doi.org/10.20517/cdr.2023.20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10571057/
https://www.ncbi.nlm.nih.gov/pubmed/37842233
http://dx.doi.org/10.20517/cdr.2023.20

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