Hyperactive KRAS/MAPK signaling disrupts normal lymphatic vessel architecture and function

Complex lymphatic anomalies (CLAs) are sporadically occurring diseases caused by the maldevelopment of lymphatic vessels. We and others recently reported that somatic activating mutations in KRAS can cause CLAs. However, the mechanisms by which activating KRAS mutations cause CLAs are poorly underst...

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Detalles Bibliográficos
Autores principales: Fernandes, Lorenzo M., Tresemer, Jeffrey, Zhang, Jing, Rios, Jonathan J., Scallan, Joshua P., Dellinger, Michael T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10571159/
https://www.ncbi.nlm.nih.gov/pubmed/37842094
http://dx.doi.org/10.3389/fcell.2023.1276333

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10571159/
https://www.ncbi.nlm.nih.gov/pubmed/37842094
http://dx.doi.org/10.3389/fcell.2023.1276333

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