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Hippocampal injections of soluble amyloid-beta oligomers alter electroencephalographic activity during wake and slow-wave sleep in rats

BACKGROUND: Soluble amyloid-beta oligomers (Aβo) begin to accumulate in the human brain one to two decades before a clinical diagnosis of Alzheimer’s disease (AD). The literature supports that soluble Aβo are implicated in synapse and neuronal losses in the brain regions such as the hippocampus. Thi...

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Detalles Bibliográficos
Autores principales: Hector, Audrey, Provost, Chloé, Delignat-Lavaud, Benoît, Bouamira, Khadija, Menaouar, Chahinez-Anissa, Mongrain, Valérie, Brouillette, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10571363/
https://www.ncbi.nlm.nih.gov/pubmed/37833786
http://dx.doi.org/10.1186/s13195-023-01316-4