Cargando…

Blockade of IL-10 Signaling Ensures Mifamurtide Efficacy in Metastatic Osteosarcoma

SIMPLE SUMMARY: Osteosarcoma is a highly aggressive and metastasizing primary bone neoplasm with poor patient survival rates. Mifamurtide is an immunostimulant drug whose clinical efficacy is still debated. Here we identified IL-10 as a new possible target useful to improve mifamurtide effectiveness...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nastasi, Nicoletta, Pasha, Amada, Bruno, Gennaro, Subbiani, Angela, Pietrovito, Laura, Leo, Angela, Scala, Lucia, de Simone, Lorena, Casazza, Gabriella, Lunardi, Federica, Taddei, Maria Letizia, Tamburini, Angela, Tondo, Annalisa, Favre, Claudio, Calvani, Maura
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10571595/ https://www.ncbi.nlm.nih.gov/pubmed/37835437 http://dx.doi.org/10.3390/cancers15194744

Ejemplares similares

Beta-Blockers and Berberine: A Possible Dual Approach to Contrast Neuroblastoma Growth and Progression
por: Calvani, Maura, et al.
Publicado: (2020)

β3-Adrenoreceptor Blockade Induces Stem Cells Differentiation in Melanoma Microenvironment
por: Calvani, Maura, et al.
Publicado: (2020)

Spotlight on ROS and β3-Adrenoreceptors Fighting in Cancer Cells
por: Calvani, Maura, et al.
Publicado: (2019)

β2-and β3-Adrenergic Receptors Contribute to Cancer-Evoked Pain in a Mouse Model of Osteosarcoma via Modulation of Neural Macrophages
por: Bruno, Gennaro, et al.
Publicado: (2021)

β3-adrenergic receptor on tumor-infiltrating lymphocytes sustains IFN-γ-dependent PD-L1 expression and impairs anti-tumor immunity in neuroblastoma
por: Bruno, Gennaro, et al.
Publicado: (2023)

Review of mifamurtide in the treatment of patients with osteosarcoma
por: Kager, Leo, et al.
Publicado: (2010)

Role of β3-Adrenergic Receptor in Bone Marrow Transplant as Therapeutical Support in Cancer
por: Nastasi, Nicoletta, et al.
Publicado: (2022)

β3-Adrenoreceptor Activity Limits Apigenin Efficacy in Ewing Sarcoma Cells: A Dual Approach to Prevent Cell Survival
por: Pasha, Amada, et al.
Publicado: (2019)

Nutraceutical Boom in Cancer: Inside the Labyrinth of Reactive Oxygen Species
por: Calvani, Maura, et al.
Publicado: (2020)

β3-Adrenoreceptors as ROS Balancer in Hematopoietic Stem Cell Transplantation
por: Pasha, Amada, et al.
Publicado: (2021)

Mifamurtide and TAM-like macrophages: effect on proliferation, migration and differentiation of osteosarcoma cells
por: Punzo, Francesca, et al.
Publicado: (2020)

Preliminary Study on β3-Adrenoreceptor as Predictor Marker of Relapse in Ewing Sarcoma Patients
por: Calvani, Maura, et al.
Publicado: (2020)

Lactate in Sarcoma Microenvironment: Much More than just a Waste Product
por: Taddei, Maria Letizia, et al.
Publicado: (2020)

β3-adrenoreceptor blockade reduces tumor growth and increases neuronal differentiation in neuroblastoma via SK2/S1P(2) modulation
por: Bruno, Gennaro, et al.
Publicado: (2019)

Improved osteosarcoma survival with addition of mifamurtide to conventional chemotherapy – Observational prospective single institution analysis
por: Múdry, Peter, et al.
Publicado: (2021)

β3-Adrenoceptors as Putative Regulator of Immune Tolerance in Cancer and Pregnancy
por: Calvani, Maura, et al.
Publicado: (2020)

Claisened Hexafluoro Inhibits Metastatic Spreading of Amoeboid Melanoma Cells
por: Leo, Angela, et al.
Publicado: (2021)

Bone marrow‐derived mesenchymal stem cells promote invasiveness and transendothelial migration of osteosarcoma cells via a mesenchymal to amoeboid transition
por: Pietrovito, Laura, et al.
Publicado: (2018)

β3-Adrenoreceptors Control Mitochondrial Dormancy in Melanoma and Embryonic Stem Cells
por: Calvani, Maura, et al.
Publicado: (2018)

Current Therapies and New Targets to Fight Melanoma: A Promising Role for the β3-Adrenoreceptor
por: Filippi, Luca, et al.
Publicado: (2020)

Outcomes from a mechanistic biomarker multi-arm and randomised study of liposomal MTP-PE (Mifamurtide) in metastatic and/or recurrent osteosarcoma (EuroSarc-Memos trial)
por: Barnes, David J., et al.
Publicado: (2022)

β3-Adrenoreceptor Blockade Reduces Hypoxic Myeloid Leukemic Cells Survival and Chemoresistance
por: Calvani, Maura, et al.
Publicado: (2020)

Etoposide-Bevacizumab a new strategy against human melanoma cells expressing stem-like traits
por: Calvani, Maura, et al.
Publicado: (2016)

Sarcome-13/OS2016 trial protocol: a multicentre, randomised, open-label, phase II trial of mifamurtide combined with postoperative chemotherapy for patients with newly diagnosed high-risk osteosarcoma
por: Brard, Caroline, et al.
Publicado: (2019)

Metabolic reprogramming ensures cancer cell survival despite oncogenic signaling blockade
por: Lue, Hui-wen, et al.
Publicado: (2017)

Metabolic shift toward oxidative phosphorylation in docetaxel resistant prostate cancer cells
por: Ippolito, Luigi, et al.
Publicado: (2016)

Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs OXPHOS and prostate cancer metastatic spread
por: Giannoni, Elisa, et al.
Publicado: (2015)

Custom-made 3D-printed prosthesis and free vascularised fibula for humeral reconstruction after osteosarcoma resection in a 13-year-old patient
por: Beltrami, Giovanni, et al.
Publicado: (2021)

Oncogenic Tyrosine Phosphatases: Novel Therapeutic Targets for Melanoma Treatment
por: Pardella, Elisa, et al.
Publicado: (2020)

Linking replication stress with heterochromatin formation
por: Nikolov, Ivaylo, et al.
Publicado: (2015)

Magnetic Resonance Cholangiopancreatography in the Diagnosis of Haemobilia
por: Casazza, Ines, et al.
Publicado: (2013)

Norepinephrine promotes tumor microenvironment reactivity through β3-adrenoreceptors during melanoma progression
por: Calvani, Maura, et al.
Publicado: (2014)

Dual HER2 Blockade: An Emerging Option in Metastatic Biliary Tract Cancer?
por: Ricci, Angela Dalia, et al.
Publicado: (2021)

The nucleoporin ALADIN regulates Aurora A localization to ensure robust mitotic spindle formation
por: Carvalhal, Sara, et al.
Publicado: (2015)

Tight Junction ZO Proteins Maintain Tissue Fluidity, Ensuring Efficient Collective Cell Migration
por: Skamrahl, Mark, et al.
Publicado: (2021)

Explosive seed dispersal depends on SPL7 to ensure sufficient copper for localized lignin deposition via laccases
por: Pérez-Antón, Miguel, et al.
Publicado: (2022)

Targeted treatment of solid tumors in pediatric precision oncology
por: Bertacca, Ilaria, et al.
Publicado: (2023)

Editorial: Precision Medicine in Oncology
por: Re, Angela, et al.
Publicado: (2018)

Funders’ responsibility to ensure value in research: a self-audit by the Health Research Board Ireland
por: Cody, Anne, et al.
Publicado: (2021)

Repair Foci as Liquid Phase Separation: Evidence and Limitations
por: Miné-Hattab, Judith, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_pei5q51fsa4la7kp18jmeq3oil