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Microglial over-pruning of synapses during development in autism-associated SCN2A-deficient mice and human cerebral organoids

Autism spectrum disorder (ASD) is a major neurodevelopmental disorder affecting 1 in 36 children in the United States. While neurons have been the focus to understand ASD, an altered neuro-immune response in the brain may be closely associated with ASD, and a neuro-immune interaction could play a ro...

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Detalles Bibliográficos
Autores principales: Yang, Yang, Wu, Jiaxiang, Zhang, Jingliang, Chen, Xiaoling, Que, Zhefu, Wettschurack, Kyle, Deming, Brody, acosta, Maria, Cui, Ningren, Eaton, Muriel, Zhao, Yuanrui, Halurkar, Manasi, Purba, Mandal, Chen, Ian, Xiao, Tiange, Suzuki, Matthew, Yuan, Chongli, Xu, Ranjie, Koss, Wendy, Du, Dongshu, Chen, Fuxue, Wu, Long-Jun, Clinic, Mayo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10571631/
https://www.ncbi.nlm.nih.gov/pubmed/37841865
http://dx.doi.org/10.21203/rs.3.rs-3270664/v1