Pan-Cancer Analysis of Patient Tumor Single-Cell Transcriptomes Identifies Promising Selective and Safe Chimeric Antigen Receptor Targets in Head and Neck Cancer

SIMPLE SUMMARY: A major barrier to success for chimeric antigen receptor (CAR) T-cell therapies in solid tumors is selecting optimal target antigens. Target antigens should be uniformly expressed by cancer cells and minimally so by healthy tissues in the body. Analyzing single-cell RNA-sequencing da...

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Detalles Bibliográficos
Autores principales: Madan, Sanna, Sinha, Sanju, Chang, Tiangen, Gutkind, J. Silvio, Cohen, Ezra E. W., Schäffer, Alejandro A., Ruppin, Eytan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10571718/
https://www.ncbi.nlm.nih.gov/pubmed/37835579
http://dx.doi.org/10.3390/cancers15194885

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10571718/
https://www.ncbi.nlm.nih.gov/pubmed/37835579
http://dx.doi.org/10.3390/cancers15194885

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