Cargando…

The Cell-Autonomous Pro-Metastatic Activities of PD-L1 in Breast Cancer Are Regulated by N-Linked Glycosylation-Dependent Activation of STAT3 and STAT1

PD-L1 has been characterized as an inhibitory immune checkpoint, leading to the suppression of potential anti-tumor immune activities in many cancer types. In view of the relatively limited efficacy of immune checkpoint blockades against PD-L1 in breast cancer, our recent study addressed the possibi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Erlichman, Nofar, Meshel, Tsipi, Baram, Tamir, Abu Raiya, Alaa, Horvitz, Tamar, Ben-Yaakov, Hagar, Ben-Baruch, Adit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10571791/ https://www.ncbi.nlm.nih.gov/pubmed/37830552 http://dx.doi.org/10.3390/cells12192338

Ejemplares similares

Tumor Cell-Autonomous Pro-Metastatic Activities of PD-L1 in Human Breast Cancer Are Mediated by PD-L1-S283 and Chemokine Axes
por: Erlichman, Nofar, et al.
Publicado: (2022)

Correction: Erlichman et al. Tumor Cell-Autonomous Pro-Metastatic Activities of PD-L1 in Human Breast Cancer Are Mediated by PD-L1-S283 and Chemokine Axes. Cancers 2022, 14, 1042
por: Erlichman, Nofar, et al.
Publicado: (2022)

Inflammation-Driven Regulation of PD-L1 and PD-L2, and Their Cross-Interactions with Protective Soluble TNFα Receptors in Human Triple-Negative Breast Cancer
por: Baram, Tamir, et al.
Publicado: (2022)

A Tumor Microenvironment-Driven Network Regulated by STAT3 and p65 Negatively Controls the Enrichment of Cancer Stem Cells in Human HR+/HER2− Breast Cancer
por: Ben-Yaakov, Hagar, et al.
Publicado: (2023)

Chemotherapy Shifts the Balance in Favor of CD8+ TNFR2+ TILs in Triple-Negative Breast Tumors
por: Baram, Tamir, et al.
Publicado: (2021)

Inflammation-Driven Breast Tumor Cell Plasticity: Stemness/EMT, Therapy Resistance and Dormancy
por: Baram, Tamir, et al.
Publicado: (2021)

Microenvironmental networks promote tumor heterogeneity and enrich for metastatic cancer stem-like cells in Luminal-A breast tumor cells
por: Weitzenfeld, Polina, et al.
Publicado: (2016)

Beyond Cell Motility: The Expanding Roles of Chemokines and Their Receptors in Malignancy
por: Morein, Dina, et al.
Publicado: (2020)

Continuous Inflammatory Stimulation Leads via Metabolic Plasticity to a Prometastatic Phenotype in Triple-Negative Breast Cancer Cells
por: Morein, Dina, et al.
Publicado: (2021)

Persistent Inflammatory Stimulation Drives the Conversion of MSCs to Inflammatory CAFs That Promote Pro-Metastatic Characteristics in Breast Cancer Cells
por: Rubinstein-Achiasaf, Linor, et al.
Publicado: (2021)

Progression of Luminal Breast Tumors Is Promoted by Ménage à Trois between the Inflammatory Cytokine TNFα and the Hormonal and Growth-Supporting Arms of the Tumor Microenvironment
por: Weitzenfeld, Polina, et al.
Publicado: (2013)

Tumor-Promoting Circuits That Regulate a Cancer-Related Chemokine Cluster: Dominance of Inflammatory Mediators Over Oncogenic Alterations
por: Leibovich-Rivkin, Tal, et al.
Publicado: (2012)

Breast Cancer: Coordinated Regulation of CCL2 Secretion by Intracellular Glycosaminoglycans and Chemokine Motifs()()
por: Lebel-Haziv, Yaeli, et al.
Publicado: (2014)

Co-Inflammatory Roles of TGFβ1 in the Presence of TNFα Drive a Pro-inflammatory Fate in Mesenchymal Stem Cells
por: Lerrer, Shalom, et al.
Publicado: (2017)

Tumor-Stroma-Inflammation Networks Promote Pro-metastatic Chemokines and Aggressiveness Characteristics in Triple-Negative Breast Cancer
por: Liubomirski, Yulia, et al.
Publicado: (2019)

The inflammatory cytokine TNFα cooperates with Ras in elevating metastasis and turns WT-Ras to a tumor-promoting entity in MCF-7 cells
por: Leibovich-Rivkin, Tal, et al.
Publicado: (2014)

Notch-Mediated Tumor-Stroma-Inflammation Networks Promote Invasive Properties and CXCL8 Expression in Triple-Negative Breast Cancer
por: Liubomirski, Yulia, et al.
Publicado: (2019)

Inflammatory mediators in breast cancer: Coordinated expression of TNFα & IL-1β with CCL2 & CCL5 and effects on epithelial-to-mesenchymal transition
por: Soria, Gali, et al.
Publicado: (2011)

On the role of STAT1 and STAT6 ADP-ribosylation in the regulation of macrophage activation
por: Begitt, Andreas, et al.
Publicado: (2018)

STAT1 inhibits STAT3 activation in esophageal squamous cell carcinoma
por: Liu, Zhaoyong, et al.
Publicado: (2018)

Modulation of STAT-1, STAT-3, and STAT-6 activities in THP-1 derived macrophages infected with two Trypanosoma cruzi strains
por: Oliveira, Melissa Martins, et al.
Publicado: (2022)

The Vicious Cycle of Melanoma-Microglia Crosstalk: Inter-Melanoma Variations in the Brain-Metastasis-Promoting IL-6/JAK/STAT3 Signaling Pathway
por: Izraely, Sivan, et al.
Publicado: (2023)

Regulation of the inflammatory profile of stromal cells in human breast cancer: prominent roles for TNF-α and the NF-κB pathway
por: Katanov, Christina, et al.
Publicado: (2015)

Stat3-induced S1PR1 expression is critical for persistent Stat3 activation in tumors
por: Lee, Heehyoung, et al.
Publicado: (2010)

STAT3 and STAT5 Activation in Solid Cancers
por: Igelmann, Sebastian, et al.
Publicado: (2019)

Mediator Kinase Phosphorylation of STAT1 S727 Promotes Growth of Neoplasms With JAK-STAT Activation
por: Nitulescu, Ioana I., et al.
Publicado: (2017)

Transcriptional regulation by STAT1 and STAT2 in the interferon JAK-STAT pathway
por: Au-Yeung, Nancy, et al.
Publicado: (2013)

STAT3 but Not STAT1 Is Required for Astrocyte Differentiation
por: Hong, Seulgi, et al.
Publicado: (2014)

Redox Regulation of STAT1 and STAT3 Signaling
por: Butturini, Elena, et al.
Publicado: (2020)

The Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression
por: Ahn, Ryuhjin, et al.
Publicado: (2017)

Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma
por: Dimberg, Lina Y, et al.
Publicado: (2012)

Kahweol Exerts Skin Moisturizing Activities by Upregulating STAT1 Activity
por: Chen, Hongxi, et al.
Publicado: (2021)

STAT6 and STAT1 Pathway Activation in Circulating Lymphocytes and Monocytes as Predictor of Treatment Response in Rheumatoid Arthritis
por: Kuuliala, Krista, et al.
Publicado: (2016)

Protein Inhibitor of Activated STAT (PIAS) Negatively Regulates the JAK/STAT Pathway by Inhibiting STAT Phosphorylation and Translocation
por: Niu, Guo-Juan, et al.
Publicado: (2018)

STAT1 and STAT3 in tumorigenesis: A matter of balance
por: Avalle, Lidia, et al.
Publicado: (2012)

Active Components with Inhibitory Activities on IFN-γ/STAT1 and IL-6/STAT3 Signaling Pathways from Caulis Trachelospermi
por: Liu, Xiao-Ting, et al.
Publicado: (2014)

Type I IFN induced IL1-Ra expression in hepatocytes is mediated by activating STAT6 through the formation of STAT2: STAT6 heterodimer
por: Wan, Lei, et al.
Publicado: (2008)

STAT1β enhances STAT1 function by protecting STAT1α from degradation in esophageal squamous cell carcinoma
por: Zhang, Ying, et al.
Publicado: (2017)

Phosphorylated Forms of STAT1, STAT3 and STAT5 Are Expressed in Proliferating but Not Involuted Infantile Hemangioma
por: Sulzberger, Lucy, et al.
Publicado: (2018)

Eriocalyxin B Inhibits STAT3 Signaling by Covalently Targeting STAT3 and Blocking Phosphorylation and Activation of STAT3
por: Yu, Xiaokui, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_jcl4sq9o3ghnm0701vl0sphb5k