Cargando…
Can the Inclusion of a Vegetable Biocholine Additive in Pig Feed Contaminated with Aflatoxin Reduce Toxicological Impacts on Animal Health and Performance?
SIMPLE SUMMARY: Our goal was to determine whether adding vegetable biocholine (VB) to pigs’ diets would minimize the negative effects caused by daily aflatoxin (B1 + B2) intake. The consumption of feed contaminated by aflatoxin reduced feed consumption and weight gain in piglets. Intake of aflatoxin...
Autores principales: | , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10571793/ https://www.ncbi.nlm.nih.gov/pubmed/37835616 http://dx.doi.org/10.3390/ani13193010 |
_version_ | 1785120084615757824 |
---|---|
author | Dazuk, Vanessa Tarasconi, Lara Molosse, Vitor Luiz Cécere, Bruno Giorgio Oliveira Deolindo, Guilherme Luiz Strapazzon, João Vitor Bottari, Nathieli Bianchi Bissacotti, Bianca Fagan Schetinger, Maria Rosa Chitolina Sareta, Laércio Mendes, Ricardo Evandro Vedovatto, Marcelo Gloria, Eduardo Micotti Paiano, Diovani Galli, Gabriela Miotto Da Silva, Aleksandro Schafer |
author_facet | Dazuk, Vanessa Tarasconi, Lara Molosse, Vitor Luiz Cécere, Bruno Giorgio Oliveira Deolindo, Guilherme Luiz Strapazzon, João Vitor Bottari, Nathieli Bianchi Bissacotti, Bianca Fagan Schetinger, Maria Rosa Chitolina Sareta, Laércio Mendes, Ricardo Evandro Vedovatto, Marcelo Gloria, Eduardo Micotti Paiano, Diovani Galli, Gabriela Miotto Da Silva, Aleksandro Schafer |
author_sort | Dazuk, Vanessa |
collection | PubMed |
description | SIMPLE SUMMARY: Our goal was to determine whether adding vegetable biocholine (VB) to pigs’ diets would minimize the negative effects caused by daily aflatoxin (B1 + B2) intake. The consumption of feed contaminated by aflatoxin reduced feed consumption and weight gain in piglets. Intake of aflatoxin in the diet also can cause subclinical intestinal and hepatic oxidative stress. VB supplementation in piglet diets had no positive effects on performance. VB showed hepaprotective potential in the face of a challenge with aflatoxin. ABSTRACT: (1) Background: This study’s objective was to determine whether adding vegetable biocholine (VB) to pigs’ diets would minimize the negative effects caused by daily aflatoxin (B1 + B2) intake. (2) Methods: We used seventy-two whole male pigs weaned at an average of 26 days and divided them into four groups with six replicates each (2 × 2 factorial). The treatments were identified as Afla0VB0 (negative control, without aflatoxin and without VB); Afla500VB0 (positive control, 500 µg/kg of aflatoxins; Afla0VB800 (800 mg/kg of VB); and Afla500VB800 (500 µg/kg of aflatoxin +800 mg/kg of VB). (3) Results: In the first 20 days of the experiment, only the pigs from Afla500VB0 had less weight gain and less feed consumption, different from the 30th to 40th day, when all treatments had lower performance than the negative control. In the liver, higher levels of oxygen-reactive species and lipid peroxidation were observed in Afla500VB0, associated with greater activity of the enzymes alanine aminotransferase and aspartate aminotransferase. In the jejunum, oxidative stress was associated with nitrous stress in Afla500VB0. An increase in splenic glutathione S-transferase activity in the Afla500VB800 animals was observed. (4) Conclusions: Consuming a diet contaminated with 500 µg/kg of aflatoxin influences the health and performance in the nursing phase in a silent way; however, it generates high economic losses for producers. When VB was added to the pigs’ diet in the face of an aflatoxin challenge, it showed hepatoprotective potential. |
format | Online Article Text |
id | pubmed-10571793 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105717932023-10-14 Can the Inclusion of a Vegetable Biocholine Additive in Pig Feed Contaminated with Aflatoxin Reduce Toxicological Impacts on Animal Health and Performance? Dazuk, Vanessa Tarasconi, Lara Molosse, Vitor Luiz Cécere, Bruno Giorgio Oliveira Deolindo, Guilherme Luiz Strapazzon, João Vitor Bottari, Nathieli Bianchi Bissacotti, Bianca Fagan Schetinger, Maria Rosa Chitolina Sareta, Laércio Mendes, Ricardo Evandro Vedovatto, Marcelo Gloria, Eduardo Micotti Paiano, Diovani Galli, Gabriela Miotto Da Silva, Aleksandro Schafer Animals (Basel) Article SIMPLE SUMMARY: Our goal was to determine whether adding vegetable biocholine (VB) to pigs’ diets would minimize the negative effects caused by daily aflatoxin (B1 + B2) intake. The consumption of feed contaminated by aflatoxin reduced feed consumption and weight gain in piglets. Intake of aflatoxin in the diet also can cause subclinical intestinal and hepatic oxidative stress. VB supplementation in piglet diets had no positive effects on performance. VB showed hepaprotective potential in the face of a challenge with aflatoxin. ABSTRACT: (1) Background: This study’s objective was to determine whether adding vegetable biocholine (VB) to pigs’ diets would minimize the negative effects caused by daily aflatoxin (B1 + B2) intake. (2) Methods: We used seventy-two whole male pigs weaned at an average of 26 days and divided them into four groups with six replicates each (2 × 2 factorial). The treatments were identified as Afla0VB0 (negative control, without aflatoxin and without VB); Afla500VB0 (positive control, 500 µg/kg of aflatoxins; Afla0VB800 (800 mg/kg of VB); and Afla500VB800 (500 µg/kg of aflatoxin +800 mg/kg of VB). (3) Results: In the first 20 days of the experiment, only the pigs from Afla500VB0 had less weight gain and less feed consumption, different from the 30th to 40th day, when all treatments had lower performance than the negative control. In the liver, higher levels of oxygen-reactive species and lipid peroxidation were observed in Afla500VB0, associated with greater activity of the enzymes alanine aminotransferase and aspartate aminotransferase. In the jejunum, oxidative stress was associated with nitrous stress in Afla500VB0. An increase in splenic glutathione S-transferase activity in the Afla500VB800 animals was observed. (4) Conclusions: Consuming a diet contaminated with 500 µg/kg of aflatoxin influences the health and performance in the nursing phase in a silent way; however, it generates high economic losses for producers. When VB was added to the pigs’ diet in the face of an aflatoxin challenge, it showed hepatoprotective potential. MDPI 2023-09-25 /pmc/articles/PMC10571793/ /pubmed/37835616 http://dx.doi.org/10.3390/ani13193010 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Dazuk, Vanessa Tarasconi, Lara Molosse, Vitor Luiz Cécere, Bruno Giorgio Oliveira Deolindo, Guilherme Luiz Strapazzon, João Vitor Bottari, Nathieli Bianchi Bissacotti, Bianca Fagan Schetinger, Maria Rosa Chitolina Sareta, Laércio Mendes, Ricardo Evandro Vedovatto, Marcelo Gloria, Eduardo Micotti Paiano, Diovani Galli, Gabriela Miotto Da Silva, Aleksandro Schafer Can the Inclusion of a Vegetable Biocholine Additive in Pig Feed Contaminated with Aflatoxin Reduce Toxicological Impacts on Animal Health and Performance? |
title | Can the Inclusion of a Vegetable Biocholine Additive in Pig Feed Contaminated with Aflatoxin Reduce Toxicological Impacts on Animal Health and Performance? |
title_full | Can the Inclusion of a Vegetable Biocholine Additive in Pig Feed Contaminated with Aflatoxin Reduce Toxicological Impacts on Animal Health and Performance? |
title_fullStr | Can the Inclusion of a Vegetable Biocholine Additive in Pig Feed Contaminated with Aflatoxin Reduce Toxicological Impacts on Animal Health and Performance? |
title_full_unstemmed | Can the Inclusion of a Vegetable Biocholine Additive in Pig Feed Contaminated with Aflatoxin Reduce Toxicological Impacts on Animal Health and Performance? |
title_short | Can the Inclusion of a Vegetable Biocholine Additive in Pig Feed Contaminated with Aflatoxin Reduce Toxicological Impacts on Animal Health and Performance? |
title_sort | can the inclusion of a vegetable biocholine additive in pig feed contaminated with aflatoxin reduce toxicological impacts on animal health and performance? |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10571793/ https://www.ncbi.nlm.nih.gov/pubmed/37835616 http://dx.doi.org/10.3390/ani13193010 |
work_keys_str_mv | AT dazukvanessa cantheinclusionofavegetablebiocholineadditiveinpigfeedcontaminatedwithaflatoxinreducetoxicologicalimpactsonanimalhealthandperformance AT tarasconilara cantheinclusionofavegetablebiocholineadditiveinpigfeedcontaminatedwithaflatoxinreducetoxicologicalimpactsonanimalhealthandperformance AT molossevitorluiz cantheinclusionofavegetablebiocholineadditiveinpigfeedcontaminatedwithaflatoxinreducetoxicologicalimpactsonanimalhealthandperformance AT cecerebrunogiorgiooliveira cantheinclusionofavegetablebiocholineadditiveinpigfeedcontaminatedwithaflatoxinreducetoxicologicalimpactsonanimalhealthandperformance AT deolindoguilhermeluiz cantheinclusionofavegetablebiocholineadditiveinpigfeedcontaminatedwithaflatoxinreducetoxicologicalimpactsonanimalhealthandperformance AT strapazzonjoaovitor cantheinclusionofavegetablebiocholineadditiveinpigfeedcontaminatedwithaflatoxinreducetoxicologicalimpactsonanimalhealthandperformance AT bottarinathielibianchi cantheinclusionofavegetablebiocholineadditiveinpigfeedcontaminatedwithaflatoxinreducetoxicologicalimpactsonanimalhealthandperformance AT bissacottibiancafagan cantheinclusionofavegetablebiocholineadditiveinpigfeedcontaminatedwithaflatoxinreducetoxicologicalimpactsonanimalhealthandperformance AT schetingermariarosachitolina cantheinclusionofavegetablebiocholineadditiveinpigfeedcontaminatedwithaflatoxinreducetoxicologicalimpactsonanimalhealthandperformance AT saretalaercio cantheinclusionofavegetablebiocholineadditiveinpigfeedcontaminatedwithaflatoxinreducetoxicologicalimpactsonanimalhealthandperformance AT mendesricardoevandro cantheinclusionofavegetablebiocholineadditiveinpigfeedcontaminatedwithaflatoxinreducetoxicologicalimpactsonanimalhealthandperformance AT vedovattomarcelo cantheinclusionofavegetablebiocholineadditiveinpigfeedcontaminatedwithaflatoxinreducetoxicologicalimpactsonanimalhealthandperformance AT gloriaeduardomicotti cantheinclusionofavegetablebiocholineadditiveinpigfeedcontaminatedwithaflatoxinreducetoxicologicalimpactsonanimalhealthandperformance AT paianodiovani cantheinclusionofavegetablebiocholineadditiveinpigfeedcontaminatedwithaflatoxinreducetoxicologicalimpactsonanimalhealthandperformance AT galligabrielamiotto cantheinclusionofavegetablebiocholineadditiveinpigfeedcontaminatedwithaflatoxinreducetoxicologicalimpactsonanimalhealthandperformance AT dasilvaaleksandroschafer cantheinclusionofavegetablebiocholineadditiveinpigfeedcontaminatedwithaflatoxinreducetoxicologicalimpactsonanimalhealthandperformance |