Novel In Vitro Models for Cell Differentiation and Drug Transport Studies of the Human Intestine

The most common in vitro model for absorption, distribution, metabolism, and excretion (ADME) purposes is currently the Caco-2 cell line. However, clear differences in gene and protein expression towards the small intestine and an, at best, fair prediction accuracy of intestinal drug absorption rest...

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Detalles Bibliográficos
Autores principales: Przybylla, Randy, Krohn, Mathias, Sellin, Marie-Luise, Frank, Marcus, Oswald, Stefan, Linnebacher, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572004/
https://www.ncbi.nlm.nih.gov/pubmed/37830585
http://dx.doi.org/10.3390/cells12192371

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572004/
https://www.ncbi.nlm.nih.gov/pubmed/37830585
http://dx.doi.org/10.3390/cells12192371

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