Axon-Autonomous Effects of the Amyloid Precursor Protein Intracellular Domain (AICD) on Kinase Signaling and Fast Axonal Transport

The amyloid precursor protein (APP) is a key molecular component of Alzheimer’s disease (AD) pathogenesis. Proteolytic APP processing generates various cleavage products, including extracellular amyloid beta (Aβ) and the cytoplasmic APP intracellular domain (AICD). Although the role of AICD in the a...

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Detalles Bibliográficos
Autores principales: König, Svenja, Schmidt, Nadine, Bechberger, Karin, Morris, Sarah, Priego, Mercedes, Zaky, Hannah, Song, Yuyu, Pielage, Jan, Brunholz, Silke, Brady, Scott T., Kins, Stefan, Morfini, Gerardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572015/
https://www.ncbi.nlm.nih.gov/pubmed/37830617
http://dx.doi.org/10.3390/cells12192403

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572015/
https://www.ncbi.nlm.nih.gov/pubmed/37830617
http://dx.doi.org/10.3390/cells12192403

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