Mimicry of microbially-derived butyrate reveals templates for potent intestinal epithelial HIF stabilizers

Microbiota-derived short-chain fatty acids, including butyrate (BA), have multiple beneficial health effects. In the colon, BA concentrations range from 10 to 20 mM and up to 95% is utilized as energy by the mucosa. BA plays a key role in epithelial-barrier regulation and anti-inflammation, and regu...

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Detalles Bibliográficos
Autores principales: Ornelas, Alfredo, Welch, Nichole, Countess, Jacob A., Zhou, Liheng, Wang, Ruth X., Dowdell, Alexander S., Colgan, Sean P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572066/
https://www.ncbi.nlm.nih.gov/pubmed/37822087
http://dx.doi.org/10.1080/19490976.2023.2267706

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572066/
https://www.ncbi.nlm.nih.gov/pubmed/37822087
http://dx.doi.org/10.1080/19490976.2023.2267706

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