Cargando…

NAD(+) Acts as a Protective Factor in Cellular Stress Response to DNA Alkylating Agents

Sulfur mustard (SM) and its derivatives are potent genotoxic agents, which have been shown to trigger the activation of poly (ADP-ribose) polymerases (PARPs) and the depletion of their substrate, nicotinamide adenine dinucleotide (NAD(+)). NAD(+) is an essential molecule involved in numerous cellula...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ruszkiewicz, Joanna, Papatheodorou, Ylea, Jäck, Nathalie, Melzig, Jasmin, Eble, Franziska, Pirker, Annika, Thomann, Marius, Haberer, Andreas, Rothmiller, Simone, Bürkle, Alexander, Mangerich, Aswin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572126/ https://www.ncbi.nlm.nih.gov/pubmed/37830610 http://dx.doi.org/10.3390/cells12192396

Ejemplares similares

Fueling genome maintenance: On the versatile roles of NAD(+) in preserving DNA integrity
por: Ruszkiewicz, Joanna A., et al.
Publicado: (2022)

Chronic senescent human mesenchymal stem cells as possible contributor to the wound healing disorder after exposure to the alkylating agent sulfur mustard
por: Rothmiller, Simone, et al.
Publicado: (2021)

Pleiotropic Cellular Functions of PARP1 in Longevity and Aging: Genome Maintenance Meets Inflammation
por: Mangerich, Aswin, et al.
Publicado: (2012)

Real-time monitoring of PARP1-dependent PARylation by ATR-FTIR spectroscopy
por: Krüger, Annika, et al.
Publicado: (2020)

Interactions of p53 with poly(ADP-ribose) and DNA induce distinct changes in protein structure as revealed by ATR-FTIR spectroscopy
por: Krüger, Annika, et al.
Publicado: (2019)

The Nucleolus and PARP1 in Cancer Biology
por: Engbrecht, Marina, et al.
Publicado: (2020)

Why structure and chain length matter: on the biological significance underlying the structural heterogeneity of poly(ADP-ribose)
por: Reber, Julia M, et al.
Publicado: (2021)

A DUAL MTOR/NAD+ ACTING GEROTHERAPY
por: Li, Jinmei, et al.
Publicado: (2023)

PARP1 and XRCC1 exhibit a reciprocal relationship in genotoxic stress response
por: Reber, Julia M., et al.
Publicado: (2022)

PARP1 catalytic variants reveal branching and chain length-specific functions of poly(ADP-ribose) in cellular physiology and stress response
por: Aberle, Lisa, et al.
Publicado: (2020)

Genomic Adaption and Mutational Patterns in a HaCaT Subline Resistant to Alkylating Agents and Ionizing Radiation
por: Ullmann, Reinhard, et al.
Publicado: (2021)

Comparative analysis of chlorambucil-induced DNA lesion formation and repair in a spectrum of different human cell systems
por: Krassnig, Sarah Ceylan, et al.
Publicado: (2023)

NAD(+) augmentation restores mitophagy and limits accelerated aging in Werner syndrome
por: Fang, Evandro F., et al.
Publicado: (2019)

A reduced form of nicotinamide riboside defines a new path for NAD(+) biosynthesis and acts as an orally bioavailable NAD(+) precursor
por: Giroud-Gerbetant, Judith, et al.
Publicado: (2019)

PARP1 protects from benzo[a]pyrene diol epoxide-induced replication stress and mutagenicity
por: Fischer, Jan M. F., et al.
Publicado: (2017)

Influence of chain length and branching on poly(ADP-ribose)–protein interactions
por: Löffler, Tobias, et al.
Publicado: (2023)

Bringing Again Noble Metal Nanoparticles to the Forefront of Cancer Therapy
por: Vlamidis, Ylea, et al.
Publicado: (2018)

The mitochondrial NAD (+) transporter (NDT1) plays important roles in cellular NAD (+) homeostasis in Arabidopsis thaliana
por: de Souza Chaves, Izabel, et al.
Publicado: (2019)

Cellular and Mitochondrial NAD Homeostasis in Health and Disease
por: Waddell, Jaylyn, et al.
Publicado: (2023)

PARP1 regulates DNA damage-induced nucleolar-nucleoplasmic shuttling of WRN and XRCC1 in a toxicant and protein-specific manner
por: Veith, Sebastian, et al.
Publicado: (2019)

“NAD-capQ” detection and quantitation of NAD caps
por: Grudzien-Nogalska, Ewa, et al.
Publicado: (2018)

Kinetics of poly(ADP-ribosyl)ation, but not PARP1 itself, determines the cell fate in response to DNA damage in vitro and in vivo
por: Schuhwerk, Harald, et al.
Publicado: (2017)

Fumarate Analogs Act as Allosteric Inhibitors of the Human Mitochondrial NAD(P)(+)-Dependent Malic Enzyme
por: Hsieh, Ju-Yi, et al.
Publicado: (2014)

Poly(ADP‐ribose)‐mediated interplay of XPA and PARP1 leads to reciprocal regulation of protein function
por: Fischer, Jan M. F., et al.
Publicado: (2014)

Metabolically distinct roles of NAD synthetase and NAD kinase define the essentiality of NAD and NADP in Mycobacterium tuberculosis
por: Sharma, Ritu, et al.
Publicado: (2023)

Cloning and Organelle Expression of Bamboo Mitochondrial Complex I Subunits Nad1, Nad2, Nad4, and Nad5 in the Yeast Saccharomyces cerevisiae
por: Tsai, Hsieh-Chin, et al.
Publicado: (2022)

NAD to the rescue
por: Tuma, Rabiya S.
Publicado: (2005)

The crosstalk of NAD, ROS and autophagy in cellular health and ageing
por: Sedlackova, Lucia, et al.
Publicado: (2020)

Role of NAD(+) in regulating cellular and metabolic signaling pathways
por: Amjad, Sara, et al.
Publicado: (2021)

NAD-seq for profiling the NAD(+) capped transcriptome of Arabidopsis thaliana
por: Yu, Xiang, et al.
Publicado: (2021)

NAD(+) Homeostasis and NAD(+)-Consuming Enzymes: Implications for Vascular Health
por: Campagna, Roberto, et al.
Publicado: (2023)

The C-terminal domain of p53 orchestrates the interplay between non-covalent and covalent poly(ADP-ribosyl)ation of p53 by PARP1
por: Fischbach, Arthur, et al.
Publicado: (2018)

Nanoconfined Crosslinked Poly(ionic liquid)s with Unprecedented Selective Swelling Properties Obtained by Alkylation in Nanophase-Separated Poly(1-vinylimidazole)-l-poly(tetrahydrofuran) Conetworks
por: Stumphauser, Tímea, et al.
Publicado: (2020)

Flavonoid Apigenin Is an Inhibitor of the NAD(+)ase CD38: Implications for Cellular NAD(+) Metabolism, Protein Acetylation, and Treatment of Metabolic Syndrome
por: Escande, Carlos, et al.
Publicado: (2013)

Listeria monocytogenes requires cellular respiration for NAD(+) regeneration and pathogenesis
por: Rivera-Lugo, Rafael, et al.
Publicado: (2022)

Quantification of localized NAD(+) changes reveals unique specificity of NAD(+) regulation in the hypothalamus
por: Johnson, Sean, et al.
Publicado: (2023)

A Multi-Endpoint Approach to Base Excision Repair Incision Activity Augmented by PARylation and DNA Damage Levels in Mice: Impact of Sex and Age
por: Winkelbeiner, Nicola, et al.
Publicado: (2020)

Mitochondrial Impairment May Increase Cellular NAD(P)H: Resazurin Oxidoreductase Activity, Perturbing the NAD(P)H-Based Viability Assays
por: Aleshin, Vasily A., et al.
Publicado: (2015)

Metabolic and Bactericidal Effects of Targeted Suppression of NadD and NadE Enzymes in Mycobacteria
por: Rodionova, Irina A., et al.
Publicado: (2014)

Evidence that the nadA motif is a bacterial riboswitch for the ubiquitous enzyme cofactor NAD(+)
por: Malkowski, Sarah N., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_o0htf2obbf2e7a458tvu1n40qt