In Cerebellar Atrophy of 12-Month-Old ATM-Null Mice, Transcriptome Upregulations Concern Most Neurotransmission and Neuropeptide Pathways, While Downregulations Affect Prominently Itpr1, Usp2 and Non-Coding RNA

The autosomal recessive disorder Ataxia-Telangiectasia is caused by a dysfunction of the stress response protein, ATM. In the nucleus of proliferating cells, ATM senses DNA double-strand breaks and coordinates their repair. This role explains T-cell dysfunction and tumour risk. However, it remains u...

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Detalles Bibliográficos
Autores principales: Reichlmeir, Marina, Canet-Pons, Júlia, Koepf, Gabriele, Nurieva, Wasifa, Duecker, Ruth Pia, Doering, Claudia, Abell, Kathryn, Key, Jana, Stokes, Matthew P., Zielen, Stefan, Schubert, Ralf, Ivics, Zoltán, Auburger, Georg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572167/
https://www.ncbi.nlm.nih.gov/pubmed/37830614
http://dx.doi.org/10.3390/cells12192399

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572167/
https://www.ncbi.nlm.nih.gov/pubmed/37830614
http://dx.doi.org/10.3390/cells12192399

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