PolyQ-Expansion Causes Mitochondria Fragmentation Independent of Huntingtin and Is Distinct from Traumatic Brain Injury (TBI)/Mechanical Stress-Mediated Fragmentation Which Results from Cell Death

Mitochondrial dysfunction has been reported in many Huntington’s disease (HD) models; however, it is unclear how these defects occur. Here, we test the hypothesis that excess pathogenic huntingtin (HTT) impairs mitochondrial homeostasis, using Drosophila genetics and pharmacological inhibitors in HD...

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Detalles Bibliográficos
Autores principales: Swinter, Kelsey, Salah, Dania, Rathnayake, Rasika, Gunawardena, Shermali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572422/
https://www.ncbi.nlm.nih.gov/pubmed/37830620
http://dx.doi.org/10.3390/cells12192406

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572422/
https://www.ncbi.nlm.nih.gov/pubmed/37830620
http://dx.doi.org/10.3390/cells12192406

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