Application of Pluronics for Enhancing Aqueous Solubility of Lipophilic Microtubule Destabilizing Compounds on the Sea Urchin Embryo Model

In screening, the dilution of DMSO stock solution of a lipophilic molecule with an assay medium often causes compound precipitation. To overcome the issue, the application of Pluronics as cosolvents was examined using a phenotypic sea urchin embryo assay that allows for the quick and facile evaluati...

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Detalles Bibliográficos
Autores principales: Semenova, Marina N., Melik-Nubarov, Nikolay S., Semenov, Victor V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572563/
https://www.ncbi.nlm.nih.gov/pubmed/37834142
http://dx.doi.org/10.3390/ijms241914695

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572563/
https://www.ncbi.nlm.nih.gov/pubmed/37834142
http://dx.doi.org/10.3390/ijms241914695

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