Synthesis and Biological Activity of a New Indenoisoquinoline Copper Derivative as a Topoisomerase I Inhibitor

Topoisomerases are interesting targets in cancer chemotherapy. Here, we describe the design and synthesis of a novel copper(II) indenoisoquinoline complex, WN198. The new organometallic compound exhibits a cytotoxic effect on five adenocarcinoma cell lines (MCF-7, MDA-MB-231, HeLa, HT-29, and DU-145...

Descripción completa

Detalles Bibliográficos
Autores principales: Molinaro, Caroline, Wambang, Nathalie, Pellegrini, Sylvain, Henry, Natacha, Lensink, Marc F., Germain, Emmanuelle, Bousquet, Till, de Ruyck, Jérôme, Cailliau, Katia, Pélinski, Lydie, Martoriati, Alain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572568/
https://www.ncbi.nlm.nih.gov/pubmed/37834037
http://dx.doi.org/10.3390/ijms241914590

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572568/
https://www.ncbi.nlm.nih.gov/pubmed/37834037
http://dx.doi.org/10.3390/ijms241914590

Ejemplares similares