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Synthesis and Biological Activity of a New Indenoisoquinoline Copper Derivative as a Topoisomerase I Inhibitor

Topoisomerases are interesting targets in cancer chemotherapy. Here, we describe the design and synthesis of a novel copper(II) indenoisoquinoline complex, WN198. The new organometallic compound exhibits a cytotoxic effect on five adenocarcinoma cell lines (MCF-7, MDA-MB-231, HeLa, HT-29, and DU-145...

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Detalles Bibliográficos
Autores principales:	Molinaro, Caroline, Wambang, Nathalie, Pellegrini, Sylvain, Henry, Natacha, Lensink, Marc F., Germain, Emmanuelle, Bousquet, Till, de Ruyck, Jérôme, Cailliau, Katia, Pélinski, Lydie, Martoriati, Alain
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572568/ https://www.ncbi.nlm.nih.gov/pubmed/37834037 http://dx.doi.org/10.3390/ijms241914590

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