Cargando…

Evaluation of the Polygenic Risk Score for Alzheimer’s Disease in Russian Patients with Dementia Using a Low-Density Hydrogel Oligonucleotide Microarray

The polygenic risk score (PRS), together with the ɛ4 allele of the APOE gene (APOE-ɛ4), has shown high potential for Alzheimer’s disease (AD) risk prediction. The aim of this study was to validate the model of polygenic risk in Russian patients with dementia. A microarray-based assay was developed t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ikonnikova, Anna, Morozova, Anna, Antonova, Olga, Ochneva, Alexandra, Fedoseeva, Elena, Abramova, Olga, Emelyanova, Marina, Filippova, Marina, Morozova, Irina, Zorkina, Yana, Syunyakov, Timur, Andryushchenko, Alisa, Andreuyk, Denis, Kostyuk, Georgy, Gryadunov, Dmitry
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572681/ https://www.ncbi.nlm.nih.gov/pubmed/37834213 http://dx.doi.org/10.3390/ijms241914765

Ejemplares similares

Alteration of Blood Immune Biomarkers in MCI Patients with Different APOE Genotypes after Cognitive Training: A 1 Year Follow-Up Cohort Study
por: Abramova, Olga, et al.
Publicado: (2023)

Suicide-Related Single Nucleotide Polymorphisms, rs4918918 and rs10903034: Association with Dementia in Older Adults
por: Abramova, Olga, et al.
Publicado: (2022)

Positive Effect of Cognitive Training in Older Adults with Different APOE Genotypes and COVID-19 History: A 1-Year Follow-Up Cohort Study
por: Zorkina, Yana, et al.
Publicado: (2022)

Associations of neuroinflammatory parameters with clinical features in patients with mild cognitive impairment and dementia
por: Zorkina, Y., et al.
Publicado: (2022)

Intranasal neuropeptide Y is most effective in some aspects of acute stress compared to melatonin, oxytocin and orexin
por: Zubkov, Eugene, et al.
Publicado: (2022)

Brain Metabolic Profile after Intranasal vs. Intraperitoneal Clomipramine Treatment in Rats with Ultrasound Model of Depression
por: Abramova, Olga, et al.
Publicado: (2021)

Protein Misfolding and Aggregation in the Brain: Common Pathogenetic Pathways in Neurodegenerative and Mental Disorders
por: Ochneva, Aleksandra, et al.
Publicado: (2022)

Neurobiological Highlights of Cognitive Impairment in Psychiatric Disorders
por: Morozova, Anna, et al.
Publicado: (2022)

Alterations of the Composition and Neurometabolic Profile of Human Gut Microbiota in Major Depressive Disorder
por: Kovtun, Alexey S., et al.
Publicado: (2022)

The Behavior and Postnatal Development in Infant and Juvenile Rats After Ultrasound-Induced Chronic Prenatal Stress
por: Abramova, Olga, et al.
Publicado: (2021)

Nano Carrier Drug Delivery Systems for the Treatment of Neuropsychiatric Disorders: Advantages and Limitations
por: Zorkina, Yana, et al.
Publicado: (2020)

Associations of Genetic Polymorphisms and Neuroimmune Markers With Some Parameters of Frontal Lobe Dysfunction in Schizophrenia
por: Morozova, Anna, et al.
Publicado: (2021)

Association of rs4680 COMT, rs6280 DRD3, and rs7322347 5HT2A With Clinical Features of Youth-Onset Schizophrenia
por: Morozova, Anna, et al.
Publicado: (2019)

Bacterial Metabolites of Human Gut Microbiota Correlating with Depression
por: Averina, Olga V., et al.
Publicado: (2020)

The Comparison of a New Ultrasound-Induced Depression Model to the Chronic Mild Stress Paradigm
por: Zorkina, Yana A., et al.
Publicado: (2019)

Genotype imputation and polygenic score estimation in northwestern Russian population
por: Kolosov, Nikita, et al.
Publicado: (2022)

The SDHD:p.H102R Variant Is Frequent in Russian Patients with Head and Neck Paragangliomas and Associated with Loss of 11p15.5 Region and Hypermethylation of H19-DMR
por: Snezhkina, Anastasiya, et al.
Publicado: (2022)

Preparation of Protein Aerogel Particles for the Development of Innovative Drug Delivery Systems
por: Lovskaya, Daria, et al.
Publicado: (2022)

Association of Alleles of Human Leukocyte Antigen Class II Genes and Severity of COVID-19 in Patients of the ‘Red Zone’ of the Endocrinology Research Center, Moscow, Russia
por: Troshina, Ekaterina, et al.
Publicado: (2022)

Incidence of the Diagnosis of Anxiety Disorders in the Russian Federation: Results of a Web-Based Survey of Psychiatrists
por: Mosolov, Sergey N., et al.
Publicado: (2021)

Synthesis of nucleotide–amino acid conjugates designed for photo-CIDNP experiments by a phosphotriester approach
por: Abramova, Tatyana V, et al.
Publicado: (2013)

Caregiving of Older Persons during the COVID-19 Pandemic in the Russian Arctic Province: Challenges and Practice
por: Golubeva, Elena, et al.
Publicado: (2022)

Oxidation of Purine Nucleotides by Triplet 3,3′,4,4′-Benzophenone Tetracarboxylic Acid in Aqueous Solution: pH-Dependence
por: Saprygina, Natalya N., et al.
Publicado: (2014)

Prevalence of high risk of ADHD among adult users of Instagram in Russian Federation
por: Potanin, S., et al.
Publicado: (2022)

Polygenic risk scores for asthma and allergic disease associate with COVID-19 severity in 9/11 responders
por: Waszczuk, Monika A., et al.
Publicado: (2023)

N-Heterocyclic Carbenes and Their Metal Complexes Based on Histidine and Histamine Derivatives of Bacteriopurpurinimide for the Combined Chemo- and Photodynamic Therapy of Cancer
por: Tikhonov, Sergey, et al.
Publicado: (2022)

Peptide LCGA-17 Attenuates Behavioral and Neurochemical Deficits in Rodent Models of PTSD and Depression
por: Malyshev, Anton V., et al.
Publicado: (2022)

Imported Plasmodium vivax Malaria in the Russian Federation from Western Sub-Saharan Africa
por: Baranova, Alla, et al.
Publicado: (2019)

Virulent Properties of Russian Bovine Viral Diarrhea Virus Strains in Experimentally Infected Calves
por: Glotov, Alexander G., et al.
Publicado: (2016)

Silver Nanostructures: Limited Sensitivity of Detection, Toxicity and Anti-Inflammation Effects
por: Morozova, Olga V.
Publicado: (2021)

Using of Open-Source Technologies for the Design and Development of a Speech Processing System Based on Stemming Methods
por: Tarasiev, Andrey, et al.
Publicado: (2020)

Chitosan Aerogel Particles as Nasal Drug Delivery Systems
por: Menshutina, Natalia, et al.
Publicado: (2022)

Toxoplasmosis and mental disorders in the Russian Federation (with special reference to schizophrenia)
por: Stepanova, Ekaterina V., et al.
Publicado: (2019)

Relative Telomere Length Is Associated with the Risk of Development and Severity of the Course of Age-Related Macular Degeneration in the Russian Population
por: Dmitrenko, Olga P., et al.
Publicado: (2023)

Analysis of the results obtained by national research groups with the Russian state cancer program for the screening of diseases of the oral mucosa and the vermillion border
por: Maksimovskaya, Lyudmila Nikolaevna, et al.
Publicado: (2020)

Patterns of sensitization to inhalant and food allergens among pediatric patients from the Moscow region (Russian Federation)
por: Voloshin, Sergei, et al.
Publicado: (2018)

Dirofilaria immitis in a child from the Russian Federation
por: Tumolskaya, Nelli Ignatievna, et al.
Publicado: (2016)

Mesenchymal Stem Cells Early Response to Low-Dose Ionizing Radiation
por: Konkova, Marina, et al.
Publicado: (2020)

Comparison of subset selection methods in linear regression in the context of health-related quality of life and substance abuse in Russia
por: Morozova, Olga, et al.
Publicado: (2015)

Cystic Fibrosis Polymorphic Variants in a Russian Population
por: Kiseleva, Anna, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_8mqhui2c5jtqjdsopimnmt4h42