Cargando…

Differential Effects of Hypothermia and SZR72 on Cerebral Kynurenine and Kynurenic Acid in a Piglet Model of Hypoxic–Ischemic Encephalopathy

Kynurenic acid (KYNA), an endogenous neuroprotectant with antiexcitotoxic, antioxidant, and anti-inflammatory effects, is synthesized through the tryptophan-kynurenine (KYN) pathway. We investigated whether brain KYN or KYNA levels were affected by asphyxia in a translational piglet model of hypoxic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Domoki, Ferenc, Tóth-Szűki, Valéria, Kovács, Viktória, Remzső, Gábor, Körmöczi, Tímea, Vécsei, László, Berkecz, Róbert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572886/ https://www.ncbi.nlm.nih.gov/pubmed/37833970 http://dx.doi.org/10.3390/ijms241914522

Ejemplares similares

The Kynurenic Acid Analog SZR72 Enhances Neuronal Activity after Asphyxia but Is Not Neuroprotective in a Translational Model of Neonatal Hypoxic Ischemic Encephalopathy
por: Kovács, Viktória, et al.
Publicado: (2021)

Inhaled H(2) or CO(2) Do Not Augment the Neuroprotective Effect of Therapeutic Hypothermia in a Severe Neonatal Hypoxic-Ischemic Encephalopathy Piglet Model
por: Kovács, Viktória, et al.
Publicado: (2020)

Kynurenic Acid and Its Analogue SZR-72 Ameliorate the Severity of Experimental Acute Necrotizing Pancreatitis
por: Balla, Zsolt, et al.
Publicado: (2021)

Brain interstitial pH changes in the subacute phase of hypoxic-ischemic encephalopathy in newborn pigs
por: Remzső, Gábor, et al.
Publicado: (2020)

Correction: Brain interstitial pH changes in the subacute phase of hypoxic-ischemic encephalopathy in newborn pigs
por: Remzső, Gábor, et al.
Publicado: (2020)

SZR-104, a Novel Kynurenic Acid Analogue with High Permeability through the Blood–Brain Barrier
por: Molnár, Kinga, et al.
Publicado: (2021)

Sensitivity of Rodent Microglia to Kynurenines in Models of Epilepsy and Inflammation In Vivo and In Vitro: Microglia Activation Is Inhibited by Kynurenic Acid and the Synthetic Analogue SZR104
por: Lajkó, Noémi, et al.
Publicado: (2020)

NMDA attenuates the neurovascular response to hypercapnia in the neonatal cerebral cortex
por: Remzső, Gábor, et al.
Publicado: (2019)

Divergent Effects of the N-Methyl-D-Aspartate Receptor Antagonist Kynurenic Acid and the Synthetic Analog SZR-72 on Microcirculatory and Mitochondrial Dysfunction in Experimental Sepsis
por: Juhász, László, et al.
Publicado: (2020)

The kynurenic acid analog SZR104 induces cytomorphological changes associated with the anti-inflammatory phenotype in cultured microglia
por: Szabo, Melinda, et al.
Publicado: (2023)

Kynurenic Acid and Its Analog SZR104 Exhibit Strong Antiinflammatory Effects and Alter the Intracellular Distribution and Methylation Patterns of H3 Histones in Immunochallenged Microglia-Enriched Cultures of Newborn Rat Brains
por: Szabo, Melinda, et al.
Publicado: (2022)

Topical dura mater application of CFA induces enhanced expression of c-fos and glutamate in rat trigeminal nucleus caudalis: attenuated by KYNA derivate (SZR72)
por: Lukács, M., et al.
Publicado: (2017)

KYNA analogue SZR72 modifies CFA-induced dural inflammation- regarding expression of pERK1/2 and IL-1β in the rat trigeminal ganglion
por: Lukács, M., et al.
Publicado: (2016)

Decreased plasma concentrations of kynurenine and kynurenic acid in schizophrenia patients
por: Markovic, M., et al.
Publicado: (2023)

The Opposite Effects of Kynurenic Acid and Different Kynurenic Acid Analogs on Tumor Necrosis Factor-α (TNF-α) Production and Tumor Necrosis Factor-Stimulated Gene-6 (TSG-6) Expression
por: Mándi, Yvette, et al.
Publicado: (2019)

Regional Differences in the Neuronal Expression of Cyclooxygenase-2 (COX-2) in the Newborn Pig Brain
por: Oláh, Orsolya, et al.
Publicado: (2012)

The Synthesis of Kynurenic Acid in Mammals: An Updated Kynurenine Aminotransferase Structural KATalogue
por: Rossi, Franca, et al.
Publicado: (2019)

Amino acids inhibit kynurenic acid formation via suppression of kynurenine uptake or kynurenic acid synthesis in rat brain in vitro
por: Sekine, Airi, et al.
Publicado: (2015)

The Metabolic Factor Kynurenic Acid of Kynurenine Pathway Predicts Major Depressive Disorder
por: Liu, Hongye, et al.
Publicado: (2018)

Serum Kynurenic Acid and Kynurenine Are Negatively Associated with the Risk of Adult Moyamoya Disease
por: Yu, Xiaofan, et al.
Publicado: (2022)

Tryptophan, Kynurenine and Kynurenic Acid Concentrations in Milk and Serum of Dairy Cows with Prototheca Mastitis
por: Bochniarz, Mariola, et al.
Publicado: (2021)

Memantine and Kynurenic Acid: Current Neuropharmacological Aspects
por: Majláth, Zsófia, et al.
Publicado: (2016)

Structural Evaluation and Electrophysiological Effects of Some Kynurenic Acid Analogs
por: Fehér, Evelin, et al.
Publicado: (2019)

Changing the Face of Kynurenines and Neurotoxicity: Therapeutic Considerations
por: Bohár, Zsuzsanna, et al.
Publicado: (2015)

Cluster headache and kynurenines
por: Tuka, Bernadett, et al.
Publicado: (2023)

Analytical Methodologies for the Characterization and Analysis of the Parent Compound and Phase I Metabolites of 4F-MDMB-BICA in Human Microsome, Urine and Blood Samples
por: Körmöczi, Tímea, et al.
Publicado: (2021)

Acute hypertrophic but not maximal strength loading transiently enhances the kynurenine pathway towards kynurenic acid
por: Joisten, Niklas, et al.
Publicado: (2020)

Effect of 4-week physical exercises on tryptophan, kynurenine and kynurenic acid content in human sweat
por: Saran, Tomasz, et al.
Publicado: (2021)

Kynurenic Acid and Its Analogs Are Beneficial Physiologic Attenuators in Bdelloid Rotifers
por: Datki, Zsolt, et al.
Publicado: (2019)

Are Kynurenines Accomplices or Principal Villains in Dementia? Maintenance of Kynurenine Metabolism
por: Tanaka, Masaru, et al.
Publicado: (2020)

Memory Enhancement with Kynurenic Acid and Its Mechanisms in Neurotransmission
por: Martos, Diána, et al.
Publicado: (2022)

The role of kynurenine pathway and kynurenic aminotransferase alleles in postpartum depression following cesarean section in Chinese women
por: Quan, Chengxuan, et al.
Publicado: (2020)

Kynurenine pathway activation and deviation to anthranilic and kynurenic acid in fibrosing chronic graft-versus-host disease
por: Orsatti, Laura, et al.
Publicado: (2021)

Kynurenine, Kynurenic Acid, Quinolinic Acid and Interleukin-6 Levels in the Serum of Patients with Autism Spectrum Disorder
por: Yildirim, Veli, et al.
Publicado: (2023)

Natural Molecules and Neuroprotection: Kynurenic Acid, Pantethine and α-Lipoic Acid
por: Tóth, Fanni, et al.
Publicado: (2021)

Kynurenic Acid Inhibits the Electrical Stimulation Induced Elevated Pituitary Adenylate Cyclase-Activating Polypeptide Expression in the TNC
por: Körtési, Tamás, et al.
Publicado: (2018)

Kynurenic acid modulates experimentally induced inflammation in the trigeminal ganglion
por: Csáti, A., et al.
Publicado: (2015)

Kynurenines, neurodegeneration and Alzheimer’s disease
por: Kincses, Zsigmond Tamas, et al.
Publicado: (2010)

The Genetic Link between Parkinson's Disease and the Kynurenine Pathway Is Still Missing
por: Török, Nóra, et al.
Publicado: (2015)

Kynurenine aminotransferase activity of Aro8/Aro9 engage tryptophan degradation by producing kynurenic acid in Saccharomyces cerevisiae
por: Ohashi, Kazuto, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_mtpt9a6nhhg7r6sgc6hn6hj6r1