How Does cGAS Avoid Sensing Self-DNA under Normal Physiological Conditions?

cGAS is a cytosolic DNA sensor that activates innate immune responses by producing the second messenger 2′3′-cGAMP, which activates the adaptor STING. cGAS senses dsDNA in a length-dependent but sequence-independent manner, meaning it cannot discriminate self-DNA from foreign DNA. In normal physiolo...

Descripción completa

Detalles Bibliográficos
Autores principales: Zheng, Wangli, Chen, Nanhua, Meurens, François, Zheng, Wanglong, Zhu, Jianzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572901/
https://www.ncbi.nlm.nih.gov/pubmed/37834184
http://dx.doi.org/10.3390/ijms241914738

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572901/
https://www.ncbi.nlm.nih.gov/pubmed/37834184
http://dx.doi.org/10.3390/ijms241914738

Ejemplares similares