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How Does cGAS Avoid Sensing Self-DNA under Normal Physiological Conditions?

cGAS is a cytosolic DNA sensor that activates innate immune responses by producing the second messenger 2′3′-cGAMP, which activates the adaptor STING. cGAS senses dsDNA in a length-dependent but sequence-independent manner, meaning it cannot discriminate self-DNA from foreign DNA. In normal physiolo...

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Detalles Bibliográficos
Autores principales:	Zheng, Wangli, Chen, Nanhua, Meurens, François, Zheng, Wanglong, Zhu, Jianzhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572901/ https://www.ncbi.nlm.nih.gov/pubmed/37834184 http://dx.doi.org/10.3390/ijms241914738

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