Structural Analysis of Janus Tyrosine Kinase Variants in Hematological Malignancies: Implications for Drug Development and Opportunities for Novel Therapeutic Strategies

Janus tyrosine kinase (JAK) variants are known drivers for hematological disorders. With the full-length structure of mouse JAK1 being recently resolved, new observations on the localization of variants within closed, open, and dimerized JAK structures are possible. Full-length homology models of hu...

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Detalles Bibliográficos
Autores principales: Rodriguez Moncivais, Omar J., Chavez, Stephanie A., Estrada Jimenez, Victor H., Sun, Shengjie, Li, Lin, Kirken, Robert A., Rodriguez, Georgialina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572942/
https://www.ncbi.nlm.nih.gov/pubmed/37834019
http://dx.doi.org/10.3390/ijms241914573

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572942/
https://www.ncbi.nlm.nih.gov/pubmed/37834019
http://dx.doi.org/10.3390/ijms241914573

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