Analytical Ultracentrifugation Detects Quaternary Rearrangements and Antibody-Induced Conformational Selection of the SARS-CoV-2 Spike Trimer

Analytical ultracentrifugation (AUC) analysis shows that the SARS-CoV-2 trimeric Spike (S) protein adopts different quaternary conformations in solution. The relative abundance of the “open” and “close” conformations is temperature-dependent, and samples with different storage temperature history ha...

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Detalles Bibliográficos
Autores principales: Guerrini, Giuditta, Mehn, Dora, Fumagalli, Francesco, Gioria, Sabrina, Pedotti, Mattia, Simonelli, Luca, Bianchini, Filippo, Robbiani, Davide F., Varani, Luca, Calzolai, Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573103/
https://www.ncbi.nlm.nih.gov/pubmed/37834322
http://dx.doi.org/10.3390/ijms241914875

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573103/
https://www.ncbi.nlm.nih.gov/pubmed/37834322
http://dx.doi.org/10.3390/ijms241914875

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