INT-767—A Dual Farnesoid-X Receptor (FXR) and Takeda G Protein-Coupled Receptor-5 (TGR5) Agonist Improves Survival in Rats and Attenuates Intestinal Ischemia Reperfusion Injury

Intestinal ischemia is a potentially catastrophic emergency, with a high rate of morbidity and mortality. Currently, no specific pharmacological treatments are available. Previous work demonstrated that pre-treatment with obeticholic acid (OCA) protected against ischemia reperfusion injury (IRI). Re...

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Detalles Bibliográficos
Autores principales: Canovai, Emilio, Farré, Ricard, Accarie, Alison, Lauriola, Mara, De Hertogh, Gert, Vanuytsel, Tim, Pirenne, Jacques, Ceulemans, Laurens J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573246/
https://www.ncbi.nlm.nih.gov/pubmed/37834329
http://dx.doi.org/10.3390/ijms241914881

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573246/
https://www.ncbi.nlm.nih.gov/pubmed/37834329
http://dx.doi.org/10.3390/ijms241914881

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