Chemical Inhibition of RPA by HAMNO Alters Cell Cycle Dynamics by Impeding DNA Replication and G2-to-M Transition but Has Little Effect on the Radiation-Induced DNA Damage Response

Replication protein A (RPA) is the major single-stranded DNA (ssDNA) binding protein that is essential for DNA replication and processing of DNA double-strand breaks (DSBs) by homology-directed repair pathways. Recently, small molecule inhibitors have been developed targeting the RPA70 subunit and p...

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Detalles Bibliográficos
Autores principales: Dueva, Rositsa, Krieger, Lisa Marie, Li, Fanghua, Luo, Daxian, Xiao, Huaping, Stuschke, Martin, Metzen, Eric, Iliakis, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573259/
https://www.ncbi.nlm.nih.gov/pubmed/37834389
http://dx.doi.org/10.3390/ijms241914941

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573259/
https://www.ncbi.nlm.nih.gov/pubmed/37834389
http://dx.doi.org/10.3390/ijms241914941

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