Generation of a new Adar1p150(−/−) mouse demonstrates isoform-specific roles in embryonic development and adult homeostasis

The RNA editing enzyme adenosine deaminase acting on RNA 1 (ADAR1) is an essential regulator of the innate immune response to both cellular and viral double-stranded RNA (dsRNA). Adenosine-to-inosine (A-to-I) editing by ADAR1 modifies the sequence and structure of endogenous dsRNA and masks it from...

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Detalles Bibliográficos
Autores principales: Liang, Zhen, Goradia, Ankita, Walkley, Carl R., Heraud-Farlow, Jacki E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2023
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573302/
https://www.ncbi.nlm.nih.gov/pubmed/37290963
http://dx.doi.org/10.1261/rna.079509.122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573302/
https://www.ncbi.nlm.nih.gov/pubmed/37290963
http://dx.doi.org/10.1261/rna.079509.122

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