Cargando…

OGR1 (GPR68) and TDAG8 (GPR65) Have Antagonistic Effects in Models of Colonic Inflammation

G-protein-coupled receptors (GPRs), including pro-inflammatory ovarian cancer GPR1 (OGR1/GPR68) and anti-inflammatory T cell death-associated gene 8 (TDAG8/GPR65), are involved in pH sensing and linked to inflammatory bowel disease (IBD). OGR1 and TDAG8 show opposite effects. To determine which effe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Perren, Leonie, Busch, Moana, Schuler, Cordelia, Ruiz, Pedro A., Foti, Federica, Weibel, Nathalie, de Vallière, Cheryl, Morsy, Yasser, Seuwen, Klaus, Hausmann, Martin, Rogler, Gerhard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573511/ https://www.ncbi.nlm.nih.gov/pubmed/37834303 http://dx.doi.org/10.3390/ijms241914855

Ejemplares similares

pH-Sensing G Protein-Coupled Receptor OGR1 (GPR68) Expression and Activation Increases in Intestinal Inflammation and Fibrosis
por: de Vallière, Cheryl, et al.
Publicado: (2022)

Hypoxia Positively Regulates the Expression of pH-Sensing G-Protein–Coupled Receptor OGR1 (GPR68)
por: de Vallière, Cheryl, et al.
Publicado: (2016)

The impact of the rs8005161 polymorphism on G protein-coupled receptor GPR65 (TDAG8) pH-associated activation in intestinal inflammation
por: Tcymbarevich, Irina V., et al.
Publicado: (2019)

Activation of pH-Sensing Receptor OGR1 (GPR68) Induces ER Stress Via the IRE1α/JNK Pathway in an Intestinal Epithelial Cell Model
por: Maeyashiki, Chiaki, et al.
Publicado: (2020)

OGR1/GPR68 Modulates the Severity of Experimental Autoimmune Encephalomyelitis and Regulates Nitric Oxide Production by Macrophages
por: D’Souza, Cheryl A., et al.
Publicado: (2016)

Clinical data analysis reveals the role of OGR1 (GPR68) in head and neck squamous cancer
por: Zhang, Wenlong, et al.
Publicado: (2020)

G Protein-coupled pH-sensing Receptor OGR1 Is a Regulator of Intestinal Inflammation
por: de Vallière, Cheryl, et al.
Publicado: (2015)

GPR68: An Emerging Drug Target in Cancer
por: Wiley, Shu Z., et al.
Publicado: (2019)

GPR68 Is a Neuroprotective Proton Receptor in Brain Ischemia
por: Wang, Tao, et al.
Publicado: (2020)

GPR68 limits the severity of chemical-induced oral epithelial dysplasia
por: Shore, David, et al.
Publicado: (2023)

Characterization of Four Orphan Receptors (GPR3, GPR6, GPR12 and GPR12L) in Chickens and Ducks and Regulation of GPR12 Expression in Ovarian Granulosa Cells by Progesterone
por: Li, Zejiao, et al.
Publicado: (2021)

Glycine Effect on the Expression Profile of Orphan Receptors GPR21, GPR26, GPR39, GPR82 and GPR6 in a Model of Inflammation in 3T3-L1 Cells
por: Gutiérrez-Rojas, Rocío Alejandra, et al.
Publicado: (2022)

The therapeutic potential of orphan GPCRs, GPR35 and GPR55
por: Shore, Derek M., et al.
Publicado: (2015)

GPR41 and GPR43 in Obesity and Inflammation – Protective or Causative?
por: Ang, Zhiwei, et al.
Publicado: (2016)

Ginseng Gintonin Contains Ligands for GPR40 and GPR55
por: Cho, Yeon-Jin, et al.
Publicado: (2020)

Natural cystatin C fragments inhibit GPR15-mediated HIV and SIV infection without interfering with GPR15L signaling
por: Hayn, Manuel, et al.
Publicado: (2021)

Potential Metabolic and Behavioural Roles of the Putative Endo- cannabinoid Receptors GPR18, GPR55 and GPR119 in Feeding
por: Ramírez-Orozco, Ricardo E., et al.
Publicado: (2019)

Pan-Cancer Analysis and Drug Formulation for GPR139 and GPR142
por: Kaushik, Aman Chandra, et al.
Publicado: (2021)

GPR68 deletion impairs hippocampal long-term potentiation and passive avoidance behavior
por: Xu, Yuanyuan, et al.
Publicado: (2020)

Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT(2) receptor reciprocally modulate their signaling functions
por: Oishi, Atsuro, et al.
Publicado: (2017)

GPR55 and GPR119 Receptors Contribute to the Processing of Neuropathic Pain in Rats
por: Zúñiga-Romero, Ángel, et al.
Publicado: (2022)

GPR119 and GPR55 as Receptors for Fatty Acid Ethanolamides, Oleoylethanolamide and Palmitoylethanolamide
por: Im, Dong-Soon
Publicado: (2021)

GPR65, a novel regulator of helper T‐cell polarization in inflammatory bowel disease
por: Hathaway‐Schrader, Jessica D., et al.
Publicado: (2022)

Compartment-Specific Activation of the Proton-Sensor GPR65 is Uncoupled from Receptor Trafficking
por: Rodríguez, Loyda M. Morales, et al.
Publicado: (2023)

Correction to: GPR68 deletion impairs hippocampal long-term potentiation and passive avoidance behavior
por: Xu, Yuanyuan, et al.
Publicado: (2021)

Expression of GPR68, an Acid-Sensing Orphan G Protein-Coupled Receptor, in Breast Cancer
por: Elemam, Noha Mousaad, et al.
Publicado: (2022)

Novel Mutations in GPR68 and SLC24A4 Cause Hypomaturation Amelogenesis Imperfecta
por: Seymen, Figen, et al.
Publicado: (2021)

Protons taken hostage: Dynamic H-bond networks of the pH-sensing GPR68
por: Kapur, Bhav, et al.
Publicado: (2023)

Receptors of intermediates of carbohydrate metabolism, GPR91 and GPR99, mediate axon growth
por: Cherif, Hosni, et al.
Publicado: (2018)

CD4(+)-mediated colitis in mice is independent of the GPR183 and GPR18 pathways
por: Dicker, Martina, et al.
Publicado: (2022)

β-Cell Inactivation of Gpr119 Unmasks Incretin Dependence of GPR119-Mediated Glucoregulation
por: Panaro, Brandon L., et al.
Publicado: (2017)

Seasonal expressions of GPR41 and GPR43 in the colon of the wild ground squirrels (Spermophilus dauricus)
por: Yang, Xiaoying, et al.
Publicado: (2022)

Emerging Roles for the Orphan GPCRs, GPR37 and GPR37 L1, in Stroke Pathophysiology
por: Mouhi, Sabra, et al.
Publicado: (2022)

Extracellular acidification stimulates GPR68 mediated IL-8 production in human pancreatic β cells
por: Chandra, Vikash, et al.
Publicado: (2016)

Mutations in the pH-Sensing G-protein-Coupled Receptor GPR68 Cause Amelogenesis Imperfecta
por: Parry, David A., et al.
Publicado: (2016)

L'ogre intérieur : de la violence personnelle et familiale /
por: Olivier, Christiane
Publicado: (1998)

Soluble Fibre Meal Challenge Reduces Airway Inflammation and Expression of GPR43 and GPR41 in Asthma
por: Halnes, Isabel, et al.
Publicado: (2017)

GPR37 and GPR37L1 differently interact with dopamine 2 receptors in live cells
por: Hertz, E., et al.
Publicado: (2019)

Mouse Mutants of Gpr37 and Gpr37l1 Receptor Genes: Disease Modeling Applications
por: Massimi, Marzia, et al.
Publicado: (2022)

Identification of Crocetin as a Dual Agonist of GPR40 and GPR120 Responsible for the Antidiabetic Effect of Saffron
por: Zhao, Xiaodi, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_3vu1am4mcgpd8b6pikbs10nhe2