Transcriptional Dysregulation and Impaired Neuronal Activity in FMR1 Knock-Out and Fragile X Patients’ iPSC-Derived Models

Fragile X syndrome (FXS) is caused by a repression of the FMR1 gene that codes the Fragile X mental retardation protein (FMRP), an RNA binding protein involved in processes that are crucial for proper brain development. To better understand the consequences of the absence of FMRP, we analyzed gene e...

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Detalles Bibliográficos
Autores principales: Maussion, Gilles, Rocha, Cecilia, Abdian, Narges, Yang, Dimitri, Turk, Julien, Carrillo Valenzuela, Dulce, Pimentel, Luisa, You, Zhipeng, Morquette, Barbara, Nicouleau, Michael, Deneault, Eric, Higgins, Samuel, Chen, Carol X.-Q., Reintsch, Wolfgang E., Ho, Stanley, Soubannier, Vincent, Lépine, Sarah, Modrusan, Zora, Lund, Jessica, Stephenson, William, Schubert, Rajib, Durcan, Thomas M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573568/
https://www.ncbi.nlm.nih.gov/pubmed/37834379
http://dx.doi.org/10.3390/ijms241914926

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573568/
https://www.ncbi.nlm.nih.gov/pubmed/37834379
http://dx.doi.org/10.3390/ijms241914926

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