Cargando…

METTL3-Mediated RNA m(6)A Modification Regulates the Angiogenic Behaviors of Retinal Endothelial Cells by Methylating MMP2 and TIE2

PURPOSE: N(6)-methyladenosine (m(6)A) is a commonly occurring modification of mRNAs, catalyzed by a complex containing methyltransferase like 3 (METTL3). Our research aims to explore how METTL3-dependent m(6)A modification affects the functions of retinal endothelial cells (RECs). METHODS: An oxygen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lin, Yong, Luo, Guangying, Liu, Qi, Yang, Rusen, Sol Reinach, Peter, Yan, Dongsheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2023
Materias:	Retinal Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573643/ https://www.ncbi.nlm.nih.gov/pubmed/37819742 http://dx.doi.org/10.1167/iovs.64.13.18

Ejemplares similares

Enhancing Retinal Endothelial Glycolysis by Inhibiting UCP2 Promotes Physiologic Retinal Vascular Development in a Model of Retinopathy of Prematurity
por: Han, Xiaokun, et al.
Publicado: (2019)

Increased Retinal Expression of the Pro-Angiogenic Receptor GPR91 via BMP6 in a Mouse Model of Juvenile Hemochromatosis
por: Arjunan, Pachiappan, et al.
Publicado: (2016)

Compound 49b Regulates ZO-1 and Occludin Levels in Human Retinal Endothelial Cells and in Mouse Retinal Vasculature
por: Jiang, Youde, et al.
Publicado: (2017)

COMP-Ang1 Stabilizes Hyperglycemic Disruption of Blood-Retinal Barrier Phenotype in Human Retinal Microvascular Endothelial Cells
por: Rochfort, Keith D., et al.
Publicado: (2019)

Adenosine Deaminase-2–Induced Hyperpermeability in Human Retinal Vascular Endothelial Cells Is Suppressed by MicroRNA-146b-3p
por: Samra, Yara A., et al.
Publicado: (2017)

Iron Accumulates in Retinal Vascular Endothelial Cells But Has Minimal Retinal Penetration After IP Iron Dextran Injection in Mice
por: Shu, Wanting, et al.
Publicado: (2019)

Downregulation of Lysyl Oxidase Protects Retinal Endothelial Cells From High Glucose–Induced Apoptosis
por: Kim, Dongjoon, et al.
Publicado: (2017)

Crosstalk Between Histone and DNA Methylation in Regulation of Retinal Matrix Metalloproteinase-9 in Diabetes
por: Duraisamy, Arul J., et al.
Publicado: (2017)

Identification of CD157-Positive Vascular Endothelial Stem Cells in Mouse Retinal and Choroidal Vessels: Fluorescence-Activated Cell Sorting Analysis
por: Wakabayashi, Taku, et al.
Publicado: (2022)

Salidroside Prevents Hypoxia-Induced Human Retinal Microvascular Endothelial Cell Damage Via miR-138/ROBO4 Axis
por: Shi, Xiaoling, et al.
Publicado: (2021)

Let-7, Lin28 and Hmga2 Expression in Ciliary Epithelium and Retinal Progenitor Cells
por: Frasson, Lorena Teixeira, et al.
Publicado: (2021)

Role of Sigma 1 Receptor in Retinal Degeneration of the Ins2(Akita/+) Murine Model of Diabetic Retinopathy
por: Wang, Jing, et al.
Publicado: (2016)

Dopamine 2 Receptor Signaling Controls the Daily Burst in Phagocytic Activity in the Mouse Retinal Pigment Epithelium
por: Goyal, Varunika, et al.
Publicado: (2020)

Low-Intensity Exercise in Mice Is Sufficient to Protect Retinal Function During Light-Induced Retinal Degeneration
por: Mees, Lukas M., et al.
Publicado: (2019)

AAV2-mediated GRP78 Transfer Alleviates Retinal Neuronal Injury by Downregulating ER Stress and Tau Oligomer Formation
por: Ha, Yonju, et al.
Publicado: (2018)

Attenuation of Microglial Activation and Pyroptosis by Inhibition of P2X7 Pathway Promotes Photoreceptor Survival in Experimental Retinal Detachment
por: Cao, Manjing, et al.
Publicado: (2023)

Expression Profiling Analysis Reveals Key MicroRNA–mRNA Interactions in Early Retinal Degeneration in Retinitis Pigmentosa
por: Anasagasti, Ander, et al.
Publicado: (2018)

Acute and Protracted Cell Death in Light-Induced Retinal Degeneration in the Canine Model of Rhodopsin Autosomal Dominant Retinitis Pigmentosa
por: Sudharsan, Raghavi, et al.
Publicado: (2017)

Granulin 1 Promotes Retinal Regeneration in Zebrafish
por: Tsuruma, Kazuhiro, et al.
Publicado: (2018)

Role of Translational Attenuation in Inherited Retinal Degeneration
por: Starr, Christopher R., et al.
Publicado: (2019)

Anatomical and Gene Expression Changes in the Retinal Pigmented Epithelium Atrophy 1 (rpea1) Mouse: A Potential Model of Serous Retinal Detachment
por: Luna, Gabriel, et al.
Publicado: (2016)

Transplanted Mouse Embryonic Stem Cell–Derived Retinal Ganglion Cells Integrate and Form Synapses in a Retinal Ganglion Cell-Depleted Mouse Model
por: Wu, You-Ren, et al.
Publicado: (2021)

MRI of Retinal Free Radical Production With Laminar Resolution In Vivo
por: Berkowitz, Bruce A., et al.
Publicado: (2016)

Role of RDS and Rhodopsin in Cngb1-Related Retinal Degeneration
por: Chakraborty, Dibyendu, et al.
Publicado: (2016)

Neuroprotective Effects of HSF1 in Retinal Ischemia-Reperfusion Injury
por: Liu, Wei, et al.
Publicado: (2019)

Conditional Müller Cell Ablation Leads to Retinal Iron Accumulation
por: Baumann, Bailey, et al.
Publicado: (2017)

Hydrogen Sulfide Contributes to Retinal Neovascularization in Ischemia-Induced Retinopathy
por: Gersztenkorn, David, et al.
Publicado: (2016)

Nestin Regulates Müller Glia Proliferation After Retinal Injury
por: Motoyoshi, Aya, et al.
Publicado: (2023)

Retinal vascular occlusion and SARS-CoV-2 vaccination
por: Vujosevic, Stela, et al.
Publicado: (2022)

Retinal Degeneration Triggers the Activation of YAP/TEAD in Reactive Müller Cells
por: Hamon, Annaïg, et al.
Publicado: (2017)

Modulation of Tmem135 Leads to Retinal Pigmented Epithelium Pathologies in Mice
por: Landowski, Michael, et al.
Publicado: (2020)

Coordinated Intervention of Microglial and Müller Cells in Light-Induced Retinal Degeneration
por: Di Pierdomenico, Johnny, et al.
Publicado: (2020)

Partially Differentiated Neuroretinal Cells Promote Maturation of the Retinal Pigment Epithelium
por: Singh, Deepti, et al.
Publicado: (2020)

Impaired Lysosome Reformation in Chloroquine-Treated Retinal Pigment Epithelial Cells
por: Cardoso, M. Helena, et al.
Publicado: (2023)

BH4-Mediated Enhancement of Endothelial Nitric Oxide Synthase Activity Reduces Hyperoxia-Induced Endothelial Damage and Preserves Vascular Integrity in the Neonate
por: Edgar, Kevin S., et al.
Publicado: (2017)

lncRNA Ttc3-209 Promotes the Apoptosis of Retinal Ganglion Cells in Retinal Ischemia Reperfusion Injury by Targeting the miR-484/Wnt8a Axis
por: Zhang, Ran, et al.
Publicado: (2021)

Epigenetic Modifications Compromise Mitochondrial DNA Quality Control in the Development of Diabetic Retinopathy
por: Mohammad, Ghulam, et al.
Publicado: (2019)

Defective Angiogenesis and Intraretinal Bleeding in Mouse Models With Disrupted Inner Retinal Lamination
por: Simmons, Aaron B., et al.
Publicado: (2016)

Potential of Small Molecule–Mediated Reprogramming of Rod Photoreceptors to Treat Retinitis Pigmentosa
por: Nakamura, Paul A., et al.
Publicado: (2016)

Retinal Glial and Choroidal Vascular Pathology in Donors Clinically Diagnosed With Stargardt Disease
por: Edwards, Malia M., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_m5ma411a455s5lae753b8s2l2a